Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

46 Citas (Scopus)


The transient receptor potential melastatin (TRPM) protein family is an extensive group of ion channels expressed in several types of mammalian cells. Many studies have shown that these channels are crucial for performing several physiological functions. Additionally, a large body of evidence indicates that these channels are also involved in numerous human diseases, known as channelopathies.A characteristic event frequently observed during pathological states is the raising in intracellular oxidative agents over reducing molecules, shifting the redox balance and inducing oxidative stress. In particular, three members of the TRPM subfamily, TRPM2, TRPM4 and TRPM7, share the remarkable feature that their activities are modulated by oxidative stress. Because of the increase in oxidative stress, these TRPM channels function aberrantly, promoting the onset and development of diseases. Increases, absences, or modifications in the function of these redox-modulated TRPM channels are associated with cell dysfunction and human pathologies. Therefore, the effect of oxidative stress on ion channels becomes an essential part of the pathogenic mechanism. Thus, oxidative stress-modulated ion channels are more susceptible to generating pathological states than oxidant-independent channels. This review examines the most relevant findings regarding the participation of the oxidative stress-modulated TRPM ion channels, TRPM2, TRPM4, and TRPM7, in human diseases. In addition, the potential roles of these channels as therapeutic tools and targets for drug design are discussed.

Idioma originalInglés
Páginas (desde-hasta)1614-1624
Número de páginas11
PublicaciónCellular Signalling
EstadoPublicada - jul 2013

Áreas temáticas de ASJC Scopus

  • Biología celular


Profundice en los temas de investigación de 'Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans'. En conjunto forman una huella única.

Citar esto