Oxidative damage associated with exposure to heavy metals present in topsoils in central Chile

Eva Madrid, José A. Pino, Sergio Muñoz, Felipe Cardemil, Felipe Martinez, Maite Berasaluce, Sebastián San Martín, Juan Reyes, Isabel González-Miranda

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Exposure to heavy metals may cause the overproduction of reactive oxygen species, generating oxidative stress and consequently, various harms to human health. The soil surrounding the Ventanas Industrial Complex, in Puchuncaví and Quintero municipal districts on the central Chilean coast, contains heavy metal concentrations (As, Cu, Pb, Zn, among others) that far exceed the maximum permissible levels established by Italian soil standards (used as a reference). This study aimed to investigate the potential association between heavy metal exposure in humans and the levels of oxidative stress biomarkers in inhabitants of these locations. We took blood samples from 140 adults living in sites with high concentrations of heavy metals in the soil and compared them with blood samples from 140 adults living in areas with normal heavy metal concentrations. We assessed lipid peroxidation, damage to genetic material, and Total Antioxidant Capacity in these blood samples. Our results indicate an association between oxidative damage and heavy metal exposure, where the inhabitants living in exposed areas have a higher level of DNA damage compared with those living in control areas. Given that DNA damage is one of the main factors in carcinogenesis, these results are of interest, both for public health and for public policies aimed at limiting human exposure to environmental pollution.

Idioma originalInglés
PublicaciónEnvironmental Geochemistry and Health
DOI
EstadoEn prensa - 2023

Áreas temáticas de ASJC Scopus

  • Ingeniería ambiental
  • Química ambiental
  • Ciencias del agua y tecnología
  • Ciencias Ambientales General
  • Geoquímica y petrología

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