Ovine placenta at high altitudes: Comparison of animals with different times of adaptation to hypoxic environment

Víctor H. Parraguez, Miljenko Atlagich, Rodrigo Díaz, Raquel Cepeda, Carlos González, Mónica De los Reyes, María E. Bruzzone, Claus Behn, Luis A. Raggi

Resultado de la investigación: Article

21 Citas (Scopus)

Resumen

Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because the placenta is a key regulator of fetal growth, the present study compared placental characteristics in term pregnancies among ewes native to HA and LA. Conception occurred at HA and ewes continued to reside at HA throughout pregnancy or conception occurred at LA and ewes were transported to HA or remained at LA (controls). Ewes native to LA were moved to HA shortly after mating (group LH) and joined with pregnant ewes native to HA (group HH). After parturition, placental cotyledons were counted and measured for total area and histological estimation of surface occupied by vasculature. The total surface of the cotyledons and surface occupied by vasculature were greater at HA, whereas the number of cotyledons was smaller at HA. These changes were more pronounced in ewes of the HH compared with the LH group. The present study showed that exposure to HA induces, in pregnant ewes, placental morphological changes that may improve maternal-fetal exchange. Moreover, because of accentuation of placental changes in ewes with long-term residence at HA, this appears to be an efficient mechanism of adaptation to hypobaric hypoxia.

Idioma originalEnglish
Páginas (desde-hasta)151-157
Número de páginas7
PublicaciónAnimal Reproduction Science
Volumen95
N.º1-2
DOI
EstadoPublished - 1 sep 2006

Huella dactilar

placenta
Placenta
Sheep
sheep
ewes
animals
Cotyledon
pregnancy
cotyledons
Pregnancy
fetal development
Fetal Development
maternal-fetal transfer
Maternal-Fetal Exchange

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

Citar esto

Parraguez, Víctor H. ; Atlagich, Miljenko ; Díaz, Rodrigo ; Cepeda, Raquel ; González, Carlos ; De los Reyes, Mónica ; Bruzzone, María E. ; Behn, Claus ; Raggi, Luis A. / Ovine placenta at high altitudes : Comparison of animals with different times of adaptation to hypoxic environment. En: Animal Reproduction Science. 2006 ; Vol. 95, N.º 1-2. pp. 151-157.
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abstract = "Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because the placenta is a key regulator of fetal growth, the present study compared placental characteristics in term pregnancies among ewes native to HA and LA. Conception occurred at HA and ewes continued to reside at HA throughout pregnancy or conception occurred at LA and ewes were transported to HA or remained at LA (controls). Ewes native to LA were moved to HA shortly after mating (group LH) and joined with pregnant ewes native to HA (group HH). After parturition, placental cotyledons were counted and measured for total area and histological estimation of surface occupied by vasculature. The total surface of the cotyledons and surface occupied by vasculature were greater at HA, whereas the number of cotyledons was smaller at HA. These changes were more pronounced in ewes of the HH compared with the LH group. The present study showed that exposure to HA induces, in pregnant ewes, placental morphological changes that may improve maternal-fetal exchange. Moreover, because of accentuation of placental changes in ewes with long-term residence at HA, this appears to be an efficient mechanism of adaptation to hypobaric hypoxia.",
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Parraguez, VH, Atlagich, M, Díaz, R, Cepeda, R, González, C, De los Reyes, M, Bruzzone, ME, Behn, C & Raggi, LA 2006, 'Ovine placenta at high altitudes: Comparison of animals with different times of adaptation to hypoxic environment', Animal Reproduction Science, vol. 95, n.º 1-2, pp. 151-157. https://doi.org/10.1016/j.anireprosci.2005.11.003

Ovine placenta at high altitudes : Comparison of animals with different times of adaptation to hypoxic environment. / Parraguez, Víctor H.; Atlagich, Miljenko; Díaz, Rodrigo; Cepeda, Raquel; González, Carlos; De los Reyes, Mónica; Bruzzone, María E.; Behn, Claus; Raggi, Luis A.

En: Animal Reproduction Science, Vol. 95, N.º 1-2, 01.09.2006, p. 151-157.

Resultado de la investigación: Article

TY - JOUR

T1 - Ovine placenta at high altitudes

T2 - Comparison of animals with different times of adaptation to hypoxic environment

AU - Parraguez, Víctor H.

AU - Atlagich, Miljenko

AU - Díaz, Rodrigo

AU - Cepeda, Raquel

AU - González, Carlos

AU - De los Reyes, Mónica

AU - Bruzzone, María E.

AU - Behn, Claus

AU - Raggi, Luis A.

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because the placenta is a key regulator of fetal growth, the present study compared placental characteristics in term pregnancies among ewes native to HA and LA. Conception occurred at HA and ewes continued to reside at HA throughout pregnancy or conception occurred at LA and ewes were transported to HA or remained at LA (controls). Ewes native to LA were moved to HA shortly after mating (group LH) and joined with pregnant ewes native to HA (group HH). After parturition, placental cotyledons were counted and measured for total area and histological estimation of surface occupied by vasculature. The total surface of the cotyledons and surface occupied by vasculature were greater at HA, whereas the number of cotyledons was smaller at HA. These changes were more pronounced in ewes of the HH compared with the LH group. The present study showed that exposure to HA induces, in pregnant ewes, placental morphological changes that may improve maternal-fetal exchange. Moreover, because of accentuation of placental changes in ewes with long-term residence at HA, this appears to be an efficient mechanism of adaptation to hypobaric hypoxia.

AB - Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because the placenta is a key regulator of fetal growth, the present study compared placental characteristics in term pregnancies among ewes native to HA and LA. Conception occurred at HA and ewes continued to reside at HA throughout pregnancy or conception occurred at LA and ewes were transported to HA or remained at LA (controls). Ewes native to LA were moved to HA shortly after mating (group LH) and joined with pregnant ewes native to HA (group HH). After parturition, placental cotyledons were counted and measured for total area and histological estimation of surface occupied by vasculature. The total surface of the cotyledons and surface occupied by vasculature were greater at HA, whereas the number of cotyledons was smaller at HA. These changes were more pronounced in ewes of the HH compared with the LH group. The present study showed that exposure to HA induces, in pregnant ewes, placental morphological changes that may improve maternal-fetal exchange. Moreover, because of accentuation of placental changes in ewes with long-term residence at HA, this appears to be an efficient mechanism of adaptation to hypobaric hypoxia.

KW - High altitude

KW - Sheep-placenta

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U2 - 10.1016/j.anireprosci.2005.11.003

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