Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: Implications for biological control in cancer

Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan

Resultado de la investigación: Contribución a los tipos de informe/libroContribución a la conferenciarevisión exhaustiva

4 Citas (Scopus)

Resumen

There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.

Idioma originalInglés
Título de la publicación alojadaSteroid Enzymes and Cancer
EditorialBlackwell Publishing Inc.
Páginas4-14
Número de páginas11
ISBN (versión impresa)9781573317450
DOI
EstadoPublicada - feb 2009

Serie de la publicación

NombreAnnals of the New York Academy of Sciences
Volumen1155
ISSN (versión impresa)0077-8923
ISSN (versión digital)1749-6632

Áreas temáticas de ASJC Scopus

  • Neurociencia (todo)
  • Bioquímica, genética y biología molecular (todo)
  • Historia y filosofía de la ciencia

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