Oral administration of insulin in winter-acclimatized carp (Cyprinus carpio) induces hepatic ultrastructural changes

María Inés Vera, Francisco Romero, Jaime Figueroa, Rodolfo Amthauer, Gloria León, Julieta Villanueva, Manuel Krauskopf

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

7 Citas (Scopus)

Resumen

1. 1. The intestinal absorption of insulin in carps was assessed examining the transepithelial passage of ingested gold-labeled hormone by electron microscopy. Insulin transfer occurred mainly through the intercellular spaces between the enterocytes. 2. 2. When reaching the lamina propria, the gold-labeled hormone gathered predominantly around the granules of the granular cells, and therefore can enter the circulatory system via the blood capillaries which are found in close contact with these cells. 3. 3. Winter-acclimatized carp were also capable of internalizing the hormone when fed with insulin. 4. 4. Furthermore, the absorbed hormone revealed full activity in regard to the observed changes in the ultrastructure of the liver cells of the treated cold-adapted fish. 5. 5. The fish ingesting the hormone underwent the same type of hepatic ultrastructure reprogramming observed when winter-acclimatized carps are injected intraperitoneally with insulin, i.e. conversion to a phenotype corresponding to hepatocytes from summer-adapted carp. 6. 6. The oral absorption of insulin by winter-acclimatized fish and its effect in reversing the cold-adaptive state might be useful for the fish culturing industry.

Idioma originalInglés
Páginas (desde-hasta)677-682
Número de páginas6
PublicaciónComparative Biochemistry and Physiology -- Part A: Physiology
Volumen106
N.º4
DOI
EstadoPublicada - dic 1993

Áreas temáticas de ASJC Scopus

  • Fisiología

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