On the Existence of Synergies and the Separability of Closed Reaction Networks

Tomas Veloz, Alejandro Bassi, Pedro Maldonado, Pablo Razeto

Resultado de la investigación: Conference contribution

Resumen

It is well known that closure is a necessary topological property for a reaction network to be dynamically stable. In this work we combine notions of chemical organization theory with structural properties of reaction networks to distill a minimal set of closed reaction networks that encodes the non-trivial stable dynamical regimes of the network. In particular, these non-trivial closed sets are synergetic, in the sense that their dynamics cannot always be computed from the dynamics of its closed constituents. We introduce a notion of separability for reaction networks and prove that it is strictly related to the notion of synergy. In particular, we provide a characterization of the non-trivial closed reaction networks by means of their degree of internal synergy. The less trivial the dynamics of the reaction network, the less can be separated into constituents, and equivalently the more synergies the reaction network has. We also discuss the computational and analytical benefits of this new representation of the dynamical structure of a reaction network.

Idioma originalEnglish
Título de la publicación alojadaMolecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers
EditoresManuel A. Martins, Madalena Chaves
EditorialSpringer Verlag
Páginas105-120
Número de páginas16
ISBN (versión impresa)9783030194314
DOI
EstadoPublished - 1 ene 2019
Evento1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018 - Santiago, Chile
Duración: 17 dic 201818 dic 2018

Serie de la publicación

NombreLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volumen11415 LNCS
ISSN (versión impresa)0302-9743
ISSN (versión digital)1611-3349

Conference

Conference1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018
PaísChile
CiudadSantiago
Período17/12/1818/12/18

Huella dactilar

Reaction Network
Synergy
Separability
Closed
Structural properties
Minimal Set
Topological Properties
Closed set
Structural Properties
Trivial
Closure
Strictly
Internal
Necessary

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Citar esto

Veloz, T., Bassi, A., Maldonado, P., & Razeto, P. (2019). On the Existence of Synergies and the Separability of Closed Reaction Networks. En M. A. Martins, & M. Chaves (Eds.), Molecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers (pp. 105-120). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11415 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-19432-1_7
Veloz, Tomas ; Bassi, Alejandro ; Maldonado, Pedro ; Razeto, Pablo. / On the Existence of Synergies and the Separability of Closed Reaction Networks. Molecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers. editor / Manuel A. Martins ; Madalena Chaves. Springer Verlag, 2019. pp. 105-120 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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Veloz, T, Bassi, A, Maldonado, P & Razeto, P 2019, On the Existence of Synergies and the Separability of Closed Reaction Networks. En MA Martins & M Chaves (eds.), Molecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11415 LNCS, Springer Verlag, pp. 105-120, 1st International Symposium on Molecular Logic and Computational Synthetic Biology, MLCSB 2018, Santiago, Chile, 17/12/18. https://doi.org/10.1007/978-3-030-19432-1_7

On the Existence of Synergies and the Separability of Closed Reaction Networks. / Veloz, Tomas; Bassi, Alejandro; Maldonado, Pedro; Razeto, Pablo.

Molecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers. ed. / Manuel A. Martins; Madalena Chaves. Springer Verlag, 2019. p. 105-120 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11415 LNCS).

Resultado de la investigación: Conference contribution

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Veloz T, Bassi A, Maldonado P, Razeto P. On the Existence of Synergies and the Separability of Closed Reaction Networks. En Martins MA, Chaves M, editores, Molecular Logic and Computational Synthetic Biology - 1st International Symposium, MLCSB 2018, Revised Selected Papers. Springer Verlag. 2019. p. 105-120. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-030-19432-1_7