Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

Pablo Valenzuela, Patrick Gray, Margarita Quiroga, Josefina Zaldivar, Howard M. Goodman, William J. Rutter

Resultado de la investigación: Article

168 Citas (Scopus)

Resumen

DNA extracted from hepatitis B virus Dane particles has been cloned in bacteria using a plasmid vector. A full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis B viral DNA encoding the surface antigen gene is reported. The amino acid sequence deduced from the DNA indicates that the surface antigen is a protein consisting of 226 amino acids and with a molecular weight of 25,398. The portion of the gene coding for this protein apparently contains no intervening sequences.

Idioma originalEnglish
Páginas (desde-hasta)815-819
Número de páginas5
PublicaciónNature
Volumen280
N.º5725
DOI
EstadoPublished - 1 dic 1979

Huella dactilar

Surface Antigens
Hepatitis B Surface Antigens
Hepatitis B virus
DNA
DNA Restriction Enzymes
Viral DNA
Hepatitis B
Base Pairing
Virion
Introns
Genes
Amino Acid Sequence
Proteins
Plasmids
Clone Cells
Molecular Weight
Bacteria
Amino Acids
IgA receptor

ASJC Scopus subject areas

  • General

Citar esto

Valenzuela, P., Gray, P., Quiroga, M., Zaldivar, J., Goodman, H. M., & Rutter, W. J. (1979). Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature, 280(5725), 815-819. https://doi.org/10.1038/280815a0
Valenzuela, Pablo ; Gray, Patrick ; Quiroga, Margarita ; Zaldivar, Josefina ; Goodman, Howard M. ; Rutter, William J. / Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. En: Nature. 1979 ; Vol. 280, N.º 5725. pp. 815-819.
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Valenzuela, P, Gray, P, Quiroga, M, Zaldivar, J, Goodman, HM & Rutter, WJ 1979, 'Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen', Nature, vol. 280, n.º 5725, pp. 815-819. https://doi.org/10.1038/280815a0

Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. / Valenzuela, Pablo; Gray, Patrick; Quiroga, Margarita; Zaldivar, Josefina; Goodman, Howard M.; Rutter, William J.

En: Nature, Vol. 280, N.º 5725, 01.12.1979, p. 815-819.

Resultado de la investigación: Article

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Valenzuela P, Gray P, Quiroga M, Zaldivar J, Goodman HM, Rutter WJ. Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature. 1979 dic 1;280(5725):815-819. https://doi.org/10.1038/280815a0