Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen

Pablo Valenzuela, Patrick Gray, Margarita Quiroga, Josefina Zaldivar, Howard M. Goodman, William J. Rutter

Resultado de la investigación: Contribución a una revistaArtículo

173 Citas (Scopus)

Resumen

DNA extracted from hepatitis B virus Dane particles has been cloned in bacteria using a plasmid vector. A full-length clone has been examined by restriction endonuclease analysis, and the nucleotide sequence of an 892-base pair fragment from cloned hepatitis B viral DNA encoding the surface antigen gene is reported. The amino acid sequence deduced from the DNA indicates that the surface antigen is a protein consisting of 226 amino acids and with a molecular weight of 25,398. The portion of the gene coding for this protein apparently contains no intervening sequences.

Idioma originalInglés
Páginas (desde-hasta)815-819
Número de páginas5
PublicaciónNature
Volumen280
N.º5725
DOI
EstadoPublicada - 1 dic 1979

Áreas temáticas de ASJC Scopus

  • General

Huella Profundice en los temas de investigación de 'Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen'. En conjunto forman una huella única.

  • Citar esto

    Valenzuela, P., Gray, P., Quiroga, M., Zaldivar, J., Goodman, H. M., & Rutter, W. J. (1979). Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature, 280(5725), 815-819. https://doi.org/10.1038/280815a0