Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs

P. Valenzuela, M. Quiroga, J. Zaldivar, W. J. Rutter, M. W. Kirschner, D. W. Cleveland

Resultado de la investigación: Article

235 Citas (Scopus)

Resumen

Most of the mRNA sequences coding for α and β tubulin in embryonic chick brain have been determined by sequencing of cloned cDNA copies of these mRNAs. From a 1,682-base pair cDNA sequence we have deduced the entire protein sequence for β tubulin. For α tubulin, all but about 38 N-terminal amino acids have been deduced from the cDNA sequence. Although tyrosine has previously been shown to be post-translationally added to the C-terminus of α tubulin by a specific ligase, we conclude that the primary post-translational event must be the removal, not the addition, of tyrosine because a terminal tyrosine is encoded by the mRNA.

Idioma originalEnglish
Páginas (desde-hasta)650-655
Número de páginas6
PublicaciónNature
Volumen289
N.º5799
DOI
EstadoPublished - 1981

Huella dactilar

Tubulin
Amino Acid Sequence
Nucleotides
Tyrosine
Messenger RNA
Complementary DNA
Ligases
Base Pairing
Amino Acids
Brain
Proteins

ASJC Scopus subject areas

  • Medicine(all)
  • General

Citar esto

Valenzuela, P., Quiroga, M., Zaldivar, J., Rutter, W. J., Kirschner, M. W., & Cleveland, D. W. (1981). Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs. Nature, 289(5799), 650-655. https://doi.org/10.1038/289650a0
Valenzuela, P. ; Quiroga, M. ; Zaldivar, J. ; Rutter, W. J. ; Kirschner, M. W. ; Cleveland, D. W. / Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs. En: Nature. 1981 ; Vol. 289, N.º 5799. pp. 650-655.
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Valenzuela, P, Quiroga, M, Zaldivar, J, Rutter, WJ, Kirschner, MW & Cleveland, DW 1981, 'Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs', Nature, vol. 289, n.º 5799, pp. 650-655. https://doi.org/10.1038/289650a0

Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs. / Valenzuela, P.; Quiroga, M.; Zaldivar, J.; Rutter, W. J.; Kirschner, M. W.; Cleveland, D. W.

En: Nature, Vol. 289, N.º 5799, 1981, p. 650-655.

Resultado de la investigación: Article

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Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs. Nature. 1981;289(5799):650-655. https://doi.org/10.1038/289650a0