Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs

P. Valenzuela, M. Quiroga, J. Zaldivar, W. J. Rutter, M. W. Kirschner, D. W. Cleveland

Resultado de la investigación: Contribución a una revistaArtículo

235 Citas (Scopus)

Resumen

Most of the mRNA sequences coding for α and β tubulin in embryonic chick brain have been determined by sequencing of cloned cDNA copies of these mRNAs. From a 1,682-base pair cDNA sequence we have deduced the entire protein sequence for β tubulin. For α tubulin, all but about 38 N-terminal amino acids have been deduced from the cDNA sequence. Although tyrosine has previously been shown to be post-translationally added to the C-terminus of α tubulin by a specific ligase, we conclude that the primary post-translational event must be the removal, not the addition, of tyrosine because a terminal tyrosine is encoded by the mRNA.

Idioma originalInglés
Páginas (desde-hasta)650-655
Número de páginas6
PublicaciónNature
Volumen289
N.º5799
DOI
EstadoPublicada - 1981

Áreas temáticas de ASJC Scopus

  • Medicina (todo)
  • General

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    Valenzuela, P., Quiroga, M., Zaldivar, J., Rutter, W. J., Kirschner, M. W., & Cleveland, D. W. (1981). Nucleotide and corresponding amino acid sequences encoded by α and β tubulin mRNAs. Nature, 289(5799), 650-655. https://doi.org/10.1038/289650a0