Nucleosome organization and targeting of SWI/SNF chromatin-remodeling complexes: Contributions of the DNA sequence

Martin Montecino, Janet L. Stein, Gary S. Stein, Jane B. Lian, Andre J. Van Wijnen, Fernando Cruzat, Soraya Gutiérrez, Juan Olate, Sylvain Marcellini, José L. Gutiérrez

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

14 Citas (Scopus)

Resumen

Chromatin organization within the nuclear compartment is a fundamental mechanism to regulate the expression of eukaryotic genes. During the last decade, a number of nuclear protein complexes with the ability to remodel chromatin and regulate gene transcription have been reported. Among these complexes is the SWI/SNF family, which alters chromatin structure in an ATP-dependent manner. A considerable effort has been made to understand the molecular mechanisms by which SWI/SNF catalyzes nucleosome remodeling. However, limited attention has been dedicated to studying the role of the DNA sequence in this remodeling process. Therefore, in this minireview, we discuss the contribution of nucleosome positioning and nucleosome excluding sequences to the targeting and activity of SWI/SNF complexes. This discussion includes results from our group using the rat osteocalcin gene promoter as a model. Based on these results, we postulate a model for chromatin remodeling and transcriptional activation of this gene in osteoblastic cells.

Idioma originalInglés
Páginas (desde-hasta)419-425
Número de páginas7
PublicaciónBiochemistry and Cell Biology
Volumen85
N.º4
DOI
EstadoPublicada - ago. 2007

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

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