Nuclear microenvironments support physiological control of gene expression

Gary S. Stein, Jane B. Lian, Martin Montecino, Janet L. Stein, André J. Van Wijnen, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young, Shirwin Pockwinse

Resultado de la investigación: Article

6 Citas (Scopus)

Resumen

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

Idioma originalEnglish
Páginas (desde-hasta)527-536
Número de páginas10
PublicaciónChromosome Research
Volumen11
N.º5
DOI
EstadoPublished - 5 sep 2003

Huella dactilar

Gene Expression
Regulator Genes
Nucleic Acids
Proteins
Transcription Factors

ASJC Scopus subject areas

  • Genetics

Citar esto

Stein, G. S., Lian, J. B., Montecino, M., Stein, J. L., Van Wijnen, A. J., Javed, A., ... Pockwinse, S. (2003). Nuclear microenvironments support physiological control of gene expression. Chromosome Research, 11(5), 527-536. https://doi.org/10.1023/A:1024943214431
Stein, Gary S. ; Lian, Jane B. ; Montecino, Martin ; Stein, Janet L. ; Van Wijnen, André J. ; Javed, Amjad ; Pratap, Jitesh ; Choi, Je ; Zaidi, S. Kaleem ; Gutierrez, Soraya ; Harrington, Kimberly ; Shen, Jiali ; Young, Daniel ; Pockwinse, Shirwin. / Nuclear microenvironments support physiological control of gene expression. En: Chromosome Research. 2003 ; Vol. 11, N.º 5. pp. 527-536.
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Stein, GS, Lian, JB, Montecino, M, Stein, JL, Van Wijnen, AJ, Javed, A, Pratap, J, Choi, J, Zaidi, SK, Gutierrez, S, Harrington, K, Shen, J, Young, D & Pockwinse, S 2003, 'Nuclear microenvironments support physiological control of gene expression', Chromosome Research, vol. 11, n.º 5, pp. 527-536. https://doi.org/10.1023/A:1024943214431

Nuclear microenvironments support physiological control of gene expression. / Stein, Gary S.; Lian, Jane B.; Montecino, Martin; Stein, Janet L.; Van Wijnen, André J.; Javed, Amjad; Pratap, Jitesh; Choi, Je; Zaidi, S. Kaleem; Gutierrez, Soraya; Harrington, Kimberly; Shen, Jiali; Young, Daniel; Pockwinse, Shirwin.

En: Chromosome Research, Vol. 11, N.º 5, 05.09.2003, p. 527-536.

Resultado de la investigación: Article

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AU - Lian, Jane B.

AU - Montecino, Martin

AU - Stein, Janet L.

AU - Van Wijnen, André J.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Choi, Je

AU - Zaidi, S. Kaleem

AU - Gutierrez, Soraya

AU - Harrington, Kimberly

AU - Shen, Jiali

AU - Young, Daniel

AU - Pockwinse, Shirwin

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KW - Chromatin

KW - Gene expression

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KW - Osteocalcin

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