Nuclear microenvironments support physiological control of gene expression

Gary S. Stein, Jane B. Lian, Martin Montecino, Janet L. Stein, André J. Van Wijnen, Amjad Javed, Jitesh Pratap, Je Choi, S. Kaleem Zaidi, Soraya Gutierrez, Kimberly Harrington, Jiali Shen, Daniel Young, Shirwin Pockwinse

Resultado de la investigación: Contribución a una revistaArtículo

6 Citas (Scopus)

Resumen

There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.

Idioma originalInglés
Páginas (desde-hasta)527-536
Número de páginas10
PublicaciónChromosome Research
Volumen11
N.º5
DOI
EstadoPublicada - 5 sep 2003

Áreas temáticas de ASJC Scopus

  • Genética

Huella Profundice en los temas de investigación de 'Nuclear microenvironments support physiological control of gene expression'. En conjunto forman una huella única.

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    Stein, G. S., Lian, J. B., Montecino, M., Stein, J. L., Van Wijnen, A. J., Javed, A., Pratap, J., Choi, J., Zaidi, S. K., Gutierrez, S., Harrington, K., Shen, J., Young, D., & Pockwinse, S. (2003). Nuclear microenvironments support physiological control of gene expression. Chromosome Research, 11(5), 527-536. https://doi.org/10.1023/A:1024943214431