Nuclear microenvironments in biological control and cancer

Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin Montecino, Andre Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Producción científica: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

138 Citas (Scopus)

Resumen

Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

Idioma originalInglés
Páginas (desde-hasta)454-463
Número de páginas10
PublicaciónNature Reviews Cancer
Volumen7
N.º6
DOI
EstadoPublicada - jun. 2007

Áreas temáticas de ASJC Scopus

  • Oncología
  • Investigación sobre el cáncer

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