Nuclear microenvironments in biological control and cancer

Sayyed K. Zaidi; Daniel W. Young; Amjad Javed; Jitesh Pratap; Martin Montecino; Andre Van Wijnen; Jane B. Lian; Janet L. Stein; Gary S. Stein

doi:10.1038/nrc2149

Nuclear microenvironments in biological control and cancer

Sayyed K. Zaidi, Daniel W. Young, Amjad Javed, Jitesh Pratap, Martin Montecino, Andre Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

139 Citas (Scopus)

Resumen

Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

Idioma original	Inglés
Páginas (desde-hasta)	454-463
Número de páginas	10
Publicación	Nature Reviews Cancer
Volumen	7
N.º	6
DOI	https://doi.org/10.1038/nrc2149
Estado	Publicada - jun. 2007

Áreas temáticas de ASJC Scopus

Oncología
Investigación sobre el cáncer

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title = "Nuclear microenvironments in biological control and cancer",

abstract = "Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.",

author = "Zaidi, {Sayyed K.} and Young, {Daniel W.} and Amjad Javed and Jitesh Pratap and Martin Montecino and {Van Wijnen}, Andre and Lian, {Jane B.} and Stein, {Janet L.} and Stein, {Gary S.}",

note = "Funding Information: Studies reported in this article were in part supported by grants from the US National Institutes of Health. The authors thank B. Bronstein for editorial assistance with the preparation of the manuscript.",

year = "2007",

month = jun,

doi = "10.1038/nrc2149",

language = "English",

volume = "7",

pages = "454--463",

journal = "Nature Reviews Cancer",

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T1 - Nuclear microenvironments in biological control and cancer

AU - Zaidi, Sayyed K.

AU - Young, Daniel W.

AU - Javed, Amjad

AU - Pratap, Jitesh

AU - Montecino, Martin

AU - Van Wijnen, Andre

AU - Lian, Jane B.

AU - Stein, Janet L.

AU - Stein, Gary S.

N1 - Funding Information: Studies reported in this article were in part supported by grants from the US National Institutes of Health. The authors thank B. Bronstein for editorial assistance with the preparation of the manuscript.

PY - 2007/6

Y1 - 2007/6

N2 - Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

AB - Nucleic acids and regulatory proteins are compartmentalized in microenvironments within the nucleus. This subnuclear organization may support convergence and the integration of physiological signals for the combinatorial control of gene expression, DNA replication and repair. Nuclear organization is modified in many cancers. There are cancer-related changes in the composition, organization and assembly of regulatory complexes at intranuclear sites. Mechanistic insights into the temporal and spatial organization of machinery for gene expression within the nucleus, which is compromised in tumours, provide a novel platform for diagnosis and therapy.

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U2 - 10.1038/nrc2149

DO - 10.1038/nrc2149

M3 - Review article

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AN - SCOPUS:34249334327

SN - 1474-175X

VL - 7

SP - 454

EP - 463

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 6

ER -

Nuclear microenvironments in biological control and cancer

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