Nogo receptor antagonizes p75NTR-dependent motor neuron death

Luc Dupuis, Mariana Pehar, Patricia Cassina, Frédèrique Rene, Raquel Castellanos, Caroline Rouaux, Mandi Gandelman, Leda Dimou, Martin E. Schwab, Jean Philippe Loeffler, Luis Barbeito, Jose Luis Gonzalez De Aguilar

Resultado de la investigación: Article

26 Citas (Scopus)

Resumen

The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

Idioma originalEnglish
Páginas (desde-hasta)740-745
Número de páginas6
PublicaciónProceedings of the National Academy of Sciences of the United States of America
Volumen105
N.º2
DOI
EstadoPublished - 15 ene 2008

Huella dactilar

Motor Neurons
Nerve Growth Factor
Axotomy
Nerve Degeneration
Nerve Growth Factors
Sciatic Nerve
Axons
Regeneration
Spinal Cord
Cell Death
Central Nervous System
Peptides
Nogo Receptor 1
Nogo Receptors

ASJC Scopus subject areas

  • General

Citar esto

Dupuis, L., Pehar, M., Cassina, P., Rene, F., Castellanos, R., Rouaux, C., ... Gonzalez De Aguilar, J. L. (2008). Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proceedings of the National Academy of Sciences of the United States of America, 105(2), 740-745. https://doi.org/10.1073/pnas.0703842105
Dupuis, Luc ; Pehar, Mariana ; Cassina, Patricia ; Rene, Frédèrique ; Castellanos, Raquel ; Rouaux, Caroline ; Gandelman, Mandi ; Dimou, Leda ; Schwab, Martin E. ; Loeffler, Jean Philippe ; Barbeito, Luis ; Gonzalez De Aguilar, Jose Luis. / Nogo receptor antagonizes p75NTR-dependent motor neuron death. En: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, N.º 2. pp. 740-745.
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title = "Nogo receptor antagonizes p75NTR-dependent motor neuron death",
abstract = "The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.",
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Dupuis, L, Pehar, M, Cassina, P, Rene, F, Castellanos, R, Rouaux, C, Gandelman, M, Dimou, L, Schwab, ME, Loeffler, JP, Barbeito, L & Gonzalez De Aguilar, JL 2008, 'Nogo receptor antagonizes p75NTR-dependent motor neuron death', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, n.º 2, pp. 740-745. https://doi.org/10.1073/pnas.0703842105

Nogo receptor antagonizes p75NTR-dependent motor neuron death. / Dupuis, Luc; Pehar, Mariana; Cassina, Patricia; Rene, Frédèrique; Castellanos, Raquel; Rouaux, Caroline; Gandelman, Mandi; Dimou, Leda; Schwab, Martin E.; Loeffler, Jean Philippe; Barbeito, Luis; Gonzalez De Aguilar, Jose Luis.

En: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, N.º 2, 15.01.2008, p. 740-745.

Resultado de la investigación: Article

TY - JOUR

T1 - Nogo receptor antagonizes p75NTR-dependent motor neuron death

AU - Dupuis, Luc

AU - Pehar, Mariana

AU - Cassina, Patricia

AU - Rene, Frédèrique

AU - Castellanos, Raquel

AU - Rouaux, Caroline

AU - Gandelman, Mandi

AU - Dimou, Leda

AU - Schwab, Martin E.

AU - Loeffler, Jean Philippe

AU - Barbeito, Luis

AU - Gonzalez De Aguilar, Jose Luis

PY - 2008/1/15

Y1 - 2008/1/15

N2 - The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

AB - The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

KW - Amyotrophic lateral sclerosis

KW - Axotomy

KW - NGF

KW - NgR

KW - Reticulon

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AN - SCOPUS:38649087009

VL - 105

SP - 740

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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