Nogo receptor antagonizes p75NTR-dependent motor neuron death

Luc Dupuis; Mariana Pehar; Patricia Cassina; Frédèrique Rene; Raquel Castellanos; Caroline Rouaux; Mandi Gandelman; Leda Dimou; Martin E. Schwab; Jean Philippe Loeffler; Luis Barbeito; Jose Luis Gonzalez De Aguilar

doi:10.1073/pnas.0703842105

Nogo receptor antagonizes p75NTR-dependent motor neuron death

Luc Dupuis, Mariana Pehar, Patricia Cassina, Frédèrique Rene, Raquel Castellanos, Caroline Rouaux, Mandi Gandelman, Leda Dimou, Martin E. Schwab, Jean Philippe Loeffler, Luis Barbeito, Jose Luis Gonzalez De Aguilar

Facultad Medicina

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

30 Citas (Scopus)

Resumen

The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

Idioma original	Inglés
Páginas (desde-hasta)	740-745
Número de páginas	6
Publicación	Proceedings of the National Academy of Sciences of the United States of America
Volumen	105
N.º	2
DOI	https://doi.org/10.1073/pnas.0703842105
Estado	Publicada - 15 ene. 2008

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Dupuis, L., Pehar, M., Cassina, P., Rene, F., Castellanos, R., Rouaux, C., Gandelman, M., Dimou, L., Schwab, M. E., Loeffler, J. P., Barbeito, L., & Gonzalez De Aguilar, J. L. (2008). Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proceedings of the National Academy of Sciences of the United States of America, 105(2), 740-745. https://doi.org/10.1073/pnas.0703842105

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title = "Nogo receptor antagonizes p75NTR-dependent motor neuron death",

abstract = "The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.",

keywords = "Amyotrophic lateral sclerosis, Axotomy, NGF, NgR, Reticulon",

author = "Luc Dupuis and Mariana Pehar and Patricia Cassina and Fr{\'e}d{\`e}rique Rene and Raquel Castellanos and Caroline Rouaux and Mandi Gandelman and Leda Dimou and Schwab, {Martin E.} and Loeffler, {Jean Philippe} and Luis Barbeito and {Gonzalez De Aguilar}, {Jose Luis}",

year = "2008",

month = jan,

day = "15",

doi = "10.1073/pnas.0703842105",

language = "English",

volume = "105",

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journal = "Proceedings of the National Academy of Sciences of the United States of America",

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publisher = "National Academy of Sciences",

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Dupuis, L, Pehar, M, Cassina, P, Rene, F, Castellanos, R, Rouaux, C, Gandelman, M, Dimou, L, Schwab, ME, Loeffler, JP, Barbeito, L & Gonzalez De Aguilar, JL 2008, 'Nogo receptor antagonizes p75NTR-dependent motor neuron death', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, n.º 2, pp. 740-745. https://doi.org/10.1073/pnas.0703842105

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T1 - Nogo receptor antagonizes p75NTR-dependent motor neuron death

AU - Dupuis, Luc

AU - Pehar, Mariana

AU - Cassina, Patricia

AU - Rene, Frédèrique

AU - Castellanos, Raquel

AU - Rouaux, Caroline

AU - Gandelman, Mandi

AU - Dimou, Leda

AU - Schwab, Martin E.

AU - Loeffler, Jean Philippe

AU - Barbeito, Luis

AU - Gonzalez De Aguilar, Jose Luis

PY - 2008/1/15

Y1 - 2008/1/15

N2 - The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

AB - The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

KW - Amyotrophic lateral sclerosis

KW - Axotomy

KW - NGF

KW - NgR

KW - Reticulon

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U2 - 10.1073/pnas.0703842105

DO - 10.1073/pnas.0703842105

M3 - Article

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AN - SCOPUS:38649087009

SN - 0027-8424

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SP - 740

EP - 745

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 2

ER -

Nogo receptor antagonizes p75NTR-dependent motor neuron death

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