Nogo receptor antagonizes p75NTR-dependent motor neuron death

Luc Dupuis, Mariana Pehar, Patricia Cassina, Frédèrique Rene, Raquel Castellanos, Caroline Rouaux, Mandi Gandelman, Leda Dimou, Martin E. Schwab, Jean Philippe Loeffler, Luis Barbeito, Jose Luis Gonzalez De Aguilar

Resultado de la investigación: Contribución a una revistaArtículo

26 Citas (Scopus)

Resumen

The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.

Idioma originalInglés
Páginas (desde-hasta)740-745
Número de páginas6
PublicaciónProceedings of the National Academy of Sciences of the United States of America
Volumen105
N.º2
DOI
EstadoPublicada - 15 ene 2008

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    Dupuis, L., Pehar, M., Cassina, P., Rene, F., Castellanos, R., Rouaux, C., Gandelman, M., Dimou, L., Schwab, M. E., Loeffler, J. P., Barbeito, L., & Gonzalez De Aguilar, J. L. (2008). Nogo receptor antagonizes p75NTR-dependent motor neuron death. Proceedings of the National Academy of Sciences of the United States of America, 105(2), 740-745. https://doi.org/10.1073/pnas.0703842105