No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lopé National Park, Gabon

Julio Andre Benavides, Sylvain Godreuil, Rebecca Bodenham, Sandra Ratiarison, Céline Devos, Marie Odile Petretto, Michel Raymond, Patricia Escobar-Páramo

Resultado de la investigación: Article

16 Citas (Scopus)

Resumen

The intensification of human activities within the habitats of wild animals is increasing the risk of interspecies disease transmission. This risk is particularly important for great apes, given their close phylogenetic relationship with humans. Areas of high human density or intense research and ecotourism activities expose apes to a high risk of disease spillover from humans. Is this risk lower in areas of low human density? We determined the prevalence of Escherichia coli antibiotic-resistant isolates in a population of the critically endangered western lowland gorilla (Gorilla gorilla gorilla) and other wild mammals in Lopé National Park (LNP), Gabon, and we tested whether the observed pattern could be explained by bacterial transmission from humans and domestic animals into wildlife populations. Our results show a high prevalence of antibiotic-resistant bacterial isolates in humans and low levels in gorillas and other wildlife. The significant differences in the genetic background of the resistant bacteria isolated from humans and gorillas suggest that transmission is low or does not occur between these two species. These findings indicate that the presence of antibiotic-resistant strains in wildlife do not imply direct bacteria transmission from humans. Thus, in areas of low human density, human-wildlife E. coli transmission seems to be low. The presence of antibiotic-resistant isolates in gorillas may be better explained by other mechanisms for resistance acquisition, such as horizontal gene exchange among bacteria or naturally acquired resistance.

Idioma originalEnglish
Páginas (desde-hasta)4281-4287
Número de páginas7
PublicaciónApplied and Environmental Microbiology
Volumen78
N.º12
DOI
EstadoPublished - 1 jun 2012

Huella dactilar

Gabon
Gorilla gorilla
Gorilla
antibiotics
national parks
lowlands
national park
Escherichia coli
Anti-Bacterial Agents
bacterium
wildlife
disease transmission
ecotourism
Hominidae
Pongidae
Bacteria
mammal
human activity
phylogenetics
bacteria

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Citar esto

Benavides, Julio Andre ; Godreuil, Sylvain ; Bodenham, Rebecca ; Ratiarison, Sandra ; Devos, Céline ; Petretto, Marie Odile ; Raymond, Michel ; Escobar-Páramo, Patricia. / No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lopé National Park, Gabon. En: Applied and Environmental Microbiology. 2012 ; Vol. 78, N.º 12. pp. 4281-4287.
@article{222b2e0ca907489b87ea639643ac85dc,
title = "No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lop{\'e} National Park, Gabon",
abstract = "The intensification of human activities within the habitats of wild animals is increasing the risk of interspecies disease transmission. This risk is particularly important for great apes, given their close phylogenetic relationship with humans. Areas of high human density or intense research and ecotourism activities expose apes to a high risk of disease spillover from humans. Is this risk lower in areas of low human density? We determined the prevalence of Escherichia coli antibiotic-resistant isolates in a population of the critically endangered western lowland gorilla (Gorilla gorilla gorilla) and other wild mammals in Lop{\'e} National Park (LNP), Gabon, and we tested whether the observed pattern could be explained by bacterial transmission from humans and domestic animals into wildlife populations. Our results show a high prevalence of antibiotic-resistant bacterial isolates in humans and low levels in gorillas and other wildlife. The significant differences in the genetic background of the resistant bacteria isolated from humans and gorillas suggest that transmission is low or does not occur between these two species. These findings indicate that the presence of antibiotic-resistant strains in wildlife do not imply direct bacteria transmission from humans. Thus, in areas of low human density, human-wildlife E. coli transmission seems to be low. The presence of antibiotic-resistant isolates in gorillas may be better explained by other mechanisms for resistance acquisition, such as horizontal gene exchange among bacteria or naturally acquired resistance.",
author = "Benavides, {Julio Andre} and Sylvain Godreuil and Rebecca Bodenham and Sandra Ratiarison and C{\'e}line Devos and Petretto, {Marie Odile} and Michel Raymond and Patricia Escobar-P{\'a}ramo",
year = "2012",
month = "6",
day = "1",
doi = "10.1128/AEM.07593-11",
language = "English",
volume = "78",
pages = "4281--4287",
journal = "Applied and Environmental Microbiology",
issn = "0099-2240",
publisher = "American Society for Microbiology",
number = "12",

}

No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lopé National Park, Gabon. / Benavides, Julio Andre; Godreuil, Sylvain; Bodenham, Rebecca; Ratiarison, Sandra; Devos, Céline; Petretto, Marie Odile; Raymond, Michel; Escobar-Páramo, Patricia.

En: Applied and Environmental Microbiology, Vol. 78, N.º 12, 01.06.2012, p. 4281-4287.

Resultado de la investigación: Article

TY - JOUR

T1 - No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lopé National Park, Gabon

AU - Benavides, Julio Andre

AU - Godreuil, Sylvain

AU - Bodenham, Rebecca

AU - Ratiarison, Sandra

AU - Devos, Céline

AU - Petretto, Marie Odile

AU - Raymond, Michel

AU - Escobar-Páramo, Patricia

PY - 2012/6/1

Y1 - 2012/6/1

N2 - The intensification of human activities within the habitats of wild animals is increasing the risk of interspecies disease transmission. This risk is particularly important for great apes, given their close phylogenetic relationship with humans. Areas of high human density or intense research and ecotourism activities expose apes to a high risk of disease spillover from humans. Is this risk lower in areas of low human density? We determined the prevalence of Escherichia coli antibiotic-resistant isolates in a population of the critically endangered western lowland gorilla (Gorilla gorilla gorilla) and other wild mammals in Lopé National Park (LNP), Gabon, and we tested whether the observed pattern could be explained by bacterial transmission from humans and domestic animals into wildlife populations. Our results show a high prevalence of antibiotic-resistant bacterial isolates in humans and low levels in gorillas and other wildlife. The significant differences in the genetic background of the resistant bacteria isolated from humans and gorillas suggest that transmission is low or does not occur between these two species. These findings indicate that the presence of antibiotic-resistant strains in wildlife do not imply direct bacteria transmission from humans. Thus, in areas of low human density, human-wildlife E. coli transmission seems to be low. The presence of antibiotic-resistant isolates in gorillas may be better explained by other mechanisms for resistance acquisition, such as horizontal gene exchange among bacteria or naturally acquired resistance.

AB - The intensification of human activities within the habitats of wild animals is increasing the risk of interspecies disease transmission. This risk is particularly important for great apes, given their close phylogenetic relationship with humans. Areas of high human density or intense research and ecotourism activities expose apes to a high risk of disease spillover from humans. Is this risk lower in areas of low human density? We determined the prevalence of Escherichia coli antibiotic-resistant isolates in a population of the critically endangered western lowland gorilla (Gorilla gorilla gorilla) and other wild mammals in Lopé National Park (LNP), Gabon, and we tested whether the observed pattern could be explained by bacterial transmission from humans and domestic animals into wildlife populations. Our results show a high prevalence of antibiotic-resistant bacterial isolates in humans and low levels in gorillas and other wildlife. The significant differences in the genetic background of the resistant bacteria isolated from humans and gorillas suggest that transmission is low or does not occur between these two species. These findings indicate that the presence of antibiotic-resistant strains in wildlife do not imply direct bacteria transmission from humans. Thus, in areas of low human density, human-wildlife E. coli transmission seems to be low. The presence of antibiotic-resistant isolates in gorillas may be better explained by other mechanisms for resistance acquisition, such as horizontal gene exchange among bacteria or naturally acquired resistance.

UR - http://www.scopus.com/inward/record.url?scp=84864105714&partnerID=8YFLogxK

U2 - 10.1128/AEM.07593-11

DO - 10.1128/AEM.07593-11

M3 - Article

VL - 78

SP - 4281

EP - 4287

JO - Applied and Environmental Microbiology

JF - Applied and Environmental Microbiology

SN - 0099-2240

IS - 12

ER -