No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice

F. C. Bronfman, I. Tesseur, M. H. Hofker, L. M. Havekens, F. Van Leuven

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

24 Citas (Scopus)

Resumen

The ε4 allele of the apolipoprotein E gene constitutes the major genetic risk factor to develop Alzheimer's disease. If and how this protein contributes to the pathological cascade of Alzheimer's disease is not known. The ε4 allele particularly affects the cholinergic defect, which is one of the most consistent neurotransmitter problems in an Alzheimer's disease brain.We have analysed several parameters of the cholinergic system in brain of apolipoprotein E knockout mice as well as in transgenic mice overexpressing human apolipoprotein E4. We analysed the distribution of cholinergic fibers, the number and morphology of cholinergic neurons and the enzymatic activity of acetylcholinesterase and choline acetyltransferase in different brain regions. Finally, we analysed the distribution and the binding parameters of [3H]hemicholinium-3, a specific marker for the high affinity choline transporter in different brain sections and regions.This extensive effort failed to show any consistent difference in the cholinergic parameters studied, in either the apolipoprotein E4 transgenic mice or in the apolipoprotein E knockout mice, compared to age-matched non-transgenic mice. We conclude that the apolipoprotein E4 is not deleterious per se for the cholinergic system in mouse brain. Copyright (C) 2000 IBRO.

Idioma originalInglés
Páginas (desde-hasta)411-418
Número de páginas8
PublicaciónNeuroscience
Volumen97
N.º3
DOI
EstadoPublicada - 1 may 2000
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Neurociencia (todo)

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