New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

Pamela A. Nieto; Catalina Pardo-Roa; Francisco J. Salazar-Echegarai; Hugo E. Tobar; Irenice Coronado-Arrázola; Claudia A. Riedel; Alexis M. Kalergis; Susan M. Bueno

doi:10.1016/j.micinf.2016.02.001

New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

Pamela A. Nieto, Catalina Pardo-Roa, Francisco J. Salazar-Echegarai, Hugo E. Tobar, Irenice Coronado-Arrázola, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno

Facultad de Ciencias de la Vida

Producción científica: Contribución a una revista › Estudio breve › revisión exhaustiva

43 Citas (Scopus)

Resumen

Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated “excisable PAIs”. Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria.

Idioma original	Inglés
Páginas (desde-hasta)	302-309
Número de páginas	8
Publicación	Microbes and Infection
Volumen	18
N.º	5
DOI	https://doi.org/10.1016/j.micinf.2016.02.001
Estado	Publicada - 1 may. 2016

Áreas temáticas de ASJC Scopus

Microbiología
Inmunología
Enfermedades infecciosas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1016/j.micinf.2016.02.001

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title = "New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence",

abstract = "Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated “excisable PAIs”. Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria.",

keywords = "Excision, Pathogenicity island, Salmonella, Virulence",

author = "Nieto, {Pamela A.} and Catalina Pardo-Roa and Salazar-Echegarai, {Francisco J.} and Tobar, {Hugo E.} and Irenice Coronado-Arr{\'a}zola and Riedel, {Claudia A.} and Kalergis, {Alexis M.} and Bueno, {Susan M.}",

note = "Funding Information: This study was supported by the following grants: Fondo Nacional de Ciencia y Tecnologia de Chile (FONDECYT numbers 11075060 , 1131012 , 1140010 and 1150862 ), Millennium Institute on Immunology and Immunotherapy P09/016-F from Iniciativa Cient{\'i}fica Milenio, Ministry of Economy of Chile ; and Grant “Nouvelles Equipes-nouvelles th{\'e}matiques” from la R{\'e}gion Pays de la Loire. PAN, CPR HET, and IC are supported by the Comisi{\'o}n Nacional de Investigaci{\'o}n Cient{\'i}fica y Tecnol{\'o}gica (CONICYT). AMK is a Chaire de la R{\'e}gion Pays de la Loire, Chercheur {\'E}tranger d'excellence, France.",

year = "2016",

month = may,

day = "1",

doi = "10.1016/j.micinf.2016.02.001",

language = "English",

volume = "18",

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journal = "Microbes and Infection",

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T1 - New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

AU - Nieto, Pamela A.

AU - Pardo-Roa, Catalina

AU - Salazar-Echegarai, Francisco J.

AU - Tobar, Hugo E.

AU - Coronado-Arrázola, Irenice

AU - Riedel, Claudia A.

AU - Kalergis, Alexis M.

AU - Bueno, Susan M.

N1 - Funding Information: This study was supported by the following grants: Fondo Nacional de Ciencia y Tecnologia de Chile (FONDECYT numbers 11075060 , 1131012 , 1140010 and 1150862 ), Millennium Institute on Immunology and Immunotherapy P09/016-F from Iniciativa Científica Milenio, Ministry of Economy of Chile ; and Grant “Nouvelles Equipes-nouvelles thématiques” from la Région Pays de la Loire. PAN, CPR HET, and IC are supported by the Comisión Nacional de Investigación Científica y Tecnológica (CONICYT). AMK is a Chaire de la Région Pays de la Loire, Chercheur Étranger d'excellence, France.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated “excisable PAIs”. Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria.

AB - Pathogenicity islands (PAIs) are regions of the chromosome of pathogenic bacteria that harbor virulence genes, which were probably acquired by lateral gene transfer. Several PAIs can excise from the bacterial chromosome by site-specific recombination and in this review have been denominated “excisable PAIs”. Here, the characteristic of some of the excisable PAIs from Salmonella enterica and the possible role and impact of the excision process on bacterial virulence is discussed. Understanding the role of PAI excision could provide important insights relative to the emergence, evolution and virulence of pathogenic enterobacteria.

KW - Excision

KW - Pathogenicity island

KW - Salmonella

KW - Virulence

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DO - 10.1016/j.micinf.2016.02.001

M3 - Short survey

AN - SCOPUS:84963976401

SN - 1286-4579

VL - 18

SP - 302

EP - 309

JO - Microbes and Infection

JF - Microbes and Infection

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New insights about excisable pathogenicity islands in Salmonella and their contribution to virulence

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Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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