Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat

W. I. Silva, H. F. Miranda, W. W. Wolstenholme, N. Cuevas, A. Ucros

Resultado de la investigación: Contribución a una revistaArtículo

3 Citas (Scopus)

Resumen

The response of post-synaptic neurokinin receptors to SP were not changed by pirenzepine or N-methyl-scopolamine. Atropine led to a slight increase in the EC50 of SP for its post-synaptic neurokinin (NK-A) receptor. In the presence of neostigmine no changes in the Emax and EC50 values of SP for its post- and pre-synaptic receptor site were observed. Only the muscarinic receptor site were observed. Only the muscarinic receptor antagonists, atropine and NMS, elicited statistically significant increases in the Emax of SP st its pre-synaptic receptor (NK-A). Addition of 7.4-740 nM SP resulted in a decrease in the EC50 and Emax values of ACh for its post-synaptic muscarinic receptor (M1). Conversely, 740 nM SP produced an increase in the EC50 and Emax values of ACh at its pre-synaptic muscarinic receptor (M2). Concentrations of 7.4 and 74 nM SP did not produce statistically significant changes in the Emax of ACh for its pre-synaptic M2 receptor.

Idioma originalInglés
Páginas (desde-hasta)153-157
Número de páginas5
PublicaciónNeuropeptides
Volumen11
N.º4
DOI
EstadoPublicada - 1988

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Endocrinología
  • Endocrinología, diabetes y metabolismo
  • Neurología clínica
  • Neurociencia (todo)
  • Neurociencia celular y molecular
  • Sistemas endocrinos y autónomos
  • Neurología
  • Medicina (todo)

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    Silva, W. I., Miranda, H. F., Wolstenholme, W. W., Cuevas, N., & Ucros, A. (1988). Neuromodulatory actions of substance P on the muscarinic receptors of the vas deferens of the rat. Neuropeptides, 11(4), 153-157. https://doi.org/10.1016/0143-4179(88)90068-6