Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

Hugo González, Daniela Elgueta, Andro Montoya, Rodrigo Pacheco

Resultado de la investigación: Contribución a una revistaArtículo de revisión

172 Citas (Scopus)

Resumen

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.

Idioma originalInglés
Páginas (desde-hasta)1-13
Número de páginas13
PublicaciónJournal of Neuroimmunology
Volumen274
N.º1-2
DOI
EstadoPublicada - 1 ene 2014

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología
  • Neurología
  • Neurología clínica

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