Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

Hugo González, Daniela Elgueta, Andro Montoya, Rodrigo Pacheco

Resultado de la investigación: Review article

151 Citas (Scopus)

Resumen

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.

Idioma originalEnglish
Páginas (desde-hasta)1-13
Número de páginas13
PublicaciónJournal of Neuroimmunology
Volumen274
N.º1-2
DOI
EstadoPublished - 1 ene 2014

Huella dactilar

Neurodegenerative Diseases
T-Lymphocytes
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier
Astrocytes
Multiple Sclerosis
Parkinson Disease
Alzheimer Disease
Central Nervous System
Neurons

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Citar esto

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Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. / González, Hugo; Elgueta, Daniela; Montoya, Andro; Pacheco, Rodrigo.

En: Journal of Neuroimmunology, Vol. 274, N.º 1-2, 01.01.2014, p. 1-13.

Resultado de la investigación: Review article

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KW - Microglia

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