Resumen
Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 1-13 |
Número de páginas | 13 |
Publicación | Journal of Neuroimmunology |
Volumen | 274 |
N.º | 1-2 |
DOI | |
Estado | Publicada - 2014 |
Áreas temáticas de ASJC Scopus
- Inmulogía y alergología
- Inmunología
- Neurología
- Neurología clínica