Neuroendocrine mechanisms of lactational infertility in women

S. Diaz, M. Seron-Ferre, H. B. Croxatto, J. Veldhuis

Resultado de la investigación: Article

12 Citas (Scopus)

Resumen

The current knowledge on the mechanisms of lactational infertility, discussed during a symposium of investigators in this subject, is reviewed. Three periods of lactation are examined: the first weeks postpartum, the period of extended lactational amenorrhea and the recovery of ovarian function. In the first postpartum weeks the inhibition of ovarian function is accounted by diminished pituitary response to GnRH, since exogenous GnRH fails to elicit a LH increase. Suckling can extend the period of ovarian inhibition for weeks, months or years, although it does not fully suppress pulsatile secretion of LH beyond the first weeks. Extended lactational amenorrhea is associated with low LH plasma levels, a great PRL increase in response to suckling, bow basal E2 levels and a suppression of estrogen positive feedback. Decreased immunoreactive LH bevels may result from partial suppression of the LH pulse generator and a smaller mass of GnRH released in each burst. The role of neurotransmitters, PRL and ovarian factors is discussed. After the recovery of ovulatory cycles suckling still has a residual infertility effect, associated to inadequate luteal function. The sources of variation among women and populations were recognized. Areas in which research is needed to improve the understanding of the mechanisms that sustain lactational amenorrhea are suggested.

Idioma originalEnglish
Páginas (desde-hasta)155-163
Número de páginas9
PublicaciónBiological Research
Volumen28
N.º2
EstadoPublished - 1995

Huella dactilar

amenorrhea
Amenorrhea
suckling
Gonadotropin-Releasing Hormone
Infertility
Postpartum Period
Fertility Agents
Recovery
Pulse generators
Corpus Luteum
Recovery of Function
postpartum period
neurotransmitters
corpus luteum
Lactation
estrogens
Neurotransmitter Agents
Estrogens
lactation
Research Personnel

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Citar esto

Diaz, S., Seron-Ferre, M., Croxatto, H. B., & Veldhuis, J. (1995). Neuroendocrine mechanisms of lactational infertility in women. Biological Research, 28(2), 155-163.
Diaz, S. ; Seron-Ferre, M. ; Croxatto, H. B. ; Veldhuis, J. / Neuroendocrine mechanisms of lactational infertility in women. En: Biological Research. 1995 ; Vol. 28, N.º 2. pp. 155-163.
@article{265e1b6783de46ae9163fcf676f2d608,
title = "Neuroendocrine mechanisms of lactational infertility in women",
abstract = "The current knowledge on the mechanisms of lactational infertility, discussed during a symposium of investigators in this subject, is reviewed. Three periods of lactation are examined: the first weeks postpartum, the period of extended lactational amenorrhea and the recovery of ovarian function. In the first postpartum weeks the inhibition of ovarian function is accounted by diminished pituitary response to GnRH, since exogenous GnRH fails to elicit a LH increase. Suckling can extend the period of ovarian inhibition for weeks, months or years, although it does not fully suppress pulsatile secretion of LH beyond the first weeks. Extended lactational amenorrhea is associated with low LH plasma levels, a great PRL increase in response to suckling, bow basal E2 levels and a suppression of estrogen positive feedback. Decreased immunoreactive LH bevels may result from partial suppression of the LH pulse generator and a smaller mass of GnRH released in each burst. The role of neurotransmitters, PRL and ovarian factors is discussed. After the recovery of ovulatory cycles suckling still has a residual infertility effect, associated to inadequate luteal function. The sources of variation among women and populations were recognized. Areas in which research is needed to improve the understanding of the mechanisms that sustain lactational amenorrhea are suggested.",
keywords = "Breast feeding, Lactational infertility, Neuroendocrine mechanisms",
author = "S. Diaz and M. Seron-Ferre and Croxatto, {H. B.} and J. Veldhuis",
year = "1995",
language = "English",
volume = "28",
pages = "155--163",
journal = "Biological Research",
issn = "0716-9760",
publisher = "Society of Biology of Chile",
number = "2",

}

Diaz, S, Seron-Ferre, M, Croxatto, HB & Veldhuis, J 1995, 'Neuroendocrine mechanisms of lactational infertility in women', Biological Research, vol. 28, n.º 2, pp. 155-163.

Neuroendocrine mechanisms of lactational infertility in women. / Diaz, S.; Seron-Ferre, M.; Croxatto, H. B.; Veldhuis, J.

En: Biological Research, Vol. 28, N.º 2, 1995, p. 155-163.

Resultado de la investigación: Article

TY - JOUR

T1 - Neuroendocrine mechanisms of lactational infertility in women

AU - Diaz, S.

AU - Seron-Ferre, M.

AU - Croxatto, H. B.

AU - Veldhuis, J.

PY - 1995

Y1 - 1995

N2 - The current knowledge on the mechanisms of lactational infertility, discussed during a symposium of investigators in this subject, is reviewed. Three periods of lactation are examined: the first weeks postpartum, the period of extended lactational amenorrhea and the recovery of ovarian function. In the first postpartum weeks the inhibition of ovarian function is accounted by diminished pituitary response to GnRH, since exogenous GnRH fails to elicit a LH increase. Suckling can extend the period of ovarian inhibition for weeks, months or years, although it does not fully suppress pulsatile secretion of LH beyond the first weeks. Extended lactational amenorrhea is associated with low LH plasma levels, a great PRL increase in response to suckling, bow basal E2 levels and a suppression of estrogen positive feedback. Decreased immunoreactive LH bevels may result from partial suppression of the LH pulse generator and a smaller mass of GnRH released in each burst. The role of neurotransmitters, PRL and ovarian factors is discussed. After the recovery of ovulatory cycles suckling still has a residual infertility effect, associated to inadequate luteal function. The sources of variation among women and populations were recognized. Areas in which research is needed to improve the understanding of the mechanisms that sustain lactational amenorrhea are suggested.

AB - The current knowledge on the mechanisms of lactational infertility, discussed during a symposium of investigators in this subject, is reviewed. Three periods of lactation are examined: the first weeks postpartum, the period of extended lactational amenorrhea and the recovery of ovarian function. In the first postpartum weeks the inhibition of ovarian function is accounted by diminished pituitary response to GnRH, since exogenous GnRH fails to elicit a LH increase. Suckling can extend the period of ovarian inhibition for weeks, months or years, although it does not fully suppress pulsatile secretion of LH beyond the first weeks. Extended lactational amenorrhea is associated with low LH plasma levels, a great PRL increase in response to suckling, bow basal E2 levels and a suppression of estrogen positive feedback. Decreased immunoreactive LH bevels may result from partial suppression of the LH pulse generator and a smaller mass of GnRH released in each burst. The role of neurotransmitters, PRL and ovarian factors is discussed. After the recovery of ovulatory cycles suckling still has a residual infertility effect, associated to inadequate luteal function. The sources of variation among women and populations were recognized. Areas in which research is needed to improve the understanding of the mechanisms that sustain lactational amenorrhea are suggested.

KW - Breast feeding

KW - Lactational infertility

KW - Neuroendocrine mechanisms

UR - http://www.scopus.com/inward/record.url?scp=0029116320&partnerID=8YFLogxK

M3 - Article

C2 - 9251745

AN - SCOPUS:0029116320

VL - 28

SP - 155

EP - 163

JO - Biological Research

JF - Biological Research

SN - 0716-9760

IS - 2

ER -