TY - JOUR
T1 - Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
AU - Funes, Samanta C.
AU - Rios, Mariana
AU - Fernández-Fierro, Ayleen
AU - Covián, Camila
AU - Bueno, Susan M.
AU - Riedel, Claudia A.
AU - Mackern-Oberti, Juan Pablo
AU - Kalergis, Alexis M.
N1 - Funding Information:
Funding. This work was supported by Corporaci?n de Fomento de la Producci?n (CORFO) Grant No. 13CTI-21526/P3 and the Millennium Institute on Immunology and Immunotherapy (P09-016-F). AK is a Helen C. Levitt Visiting Professor at the Department of Microbiology and Immunology of the University of Iowa.
Publisher Copyright:
© Copyright © 2020 Funes, Rios, Fernández-Fierro, Covián, Bueno, Riedel, Mackern-Oberti and Kalergis.
PY - 2020/7/23
Y1 - 2020/7/23
N2 - Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
AB - Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
KW - autoimmunity
KW - heme oxygenase 1
KW - HO-1
KW - inflammation
KW - naturally derived compounds
UR - http://www.scopus.com/inward/record.url?scp=85089097347&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.01467
DO - 10.3389/fimmu.2020.01467
M3 - Review article
C2 - 32849503
AN - SCOPUS:85089097347
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1467
ER -
