Natural resistance to effects of morphine in Octodon degus: A South American rodent

C. Paeile, S. Contreras, H. Miranda

Resultado de la investigación: Article

3 Citas (Scopus)

Resumen

Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.

Idioma originalEnglish
Páginas (desde-hasta)11-22
Número de páginas12
PublicaciónResearch Communications in Substances of Abuse
Volumen5
N.º1
EstadoPublished - 1984

Huella dactilar

Octodon
Innate Immunity
Morphine
Rodentia
Pentazocine
Electroencephalography
Pimozide
Endorphins
Leucine Enkephalin
Vas Deferens
Opioid Receptors
Respiratory Rate
Brain

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Citar esto

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abstract = "Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.",
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Natural resistance to effects of morphine in Octodon degus : A South American rodent. / Paeile, C.; Contreras, S.; Miranda, H.

En: Research Communications in Substances of Abuse, Vol. 5, N.º 1, 1984, p. 11-22.

Resultado de la investigación: Article

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