Resumen
Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 11-22 |
| Número de páginas | 12 |
| Publicación | Research Communications in Substances of Abuse |
| Volumen | 5 |
| N.º | 1 |
| Estado | Published - 1984 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
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Natural resistance to effects of morphine in Octodon degus : A South American rodent. / Paeile, C.; Contreras, S.; Miranda, H.
En: Research Communications in Substances of Abuse, Vol. 5, N.º 1, 1984, p. 11-22.Resultado de la investigación: Article
TY - JOUR
T1 - Natural resistance to effects of morphine in Octodon degus
T2 - A South American rodent
AU - Paeile, C.
AU - Contreras, S.
AU - Miranda, H.
PY - 1984
Y1 - 1984
N2 - Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.
AB - Octodon degus a South American caviomorph, presents a natural resistance to some effects of morphine. On respiratory rate none of the doses of morphine (i.v.) employed produced a significant modification of this parameter. The administration of morphine, leu-enkephalin and β-endorphin to isolated O. degus vas deferens did not change significantly the electrically induced muscular twitch. Brain concentration of 14C morphine in the rat, as compared to O. degus, showed statistically significant differences. Pentazocine modified the EEG of O. degus, while morphine had no effect. Pimozide produced only a partial change of the pentazocine effect on EEG. This result is consistent with the view that pentazocine interacts with different opiate receptors.
UR - http://www.scopus.com/inward/record.url?scp=0021638114&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0021638114
VL - 5
SP - 11
EP - 22
JO - Research Communications in Substances of Abuse
JF - Research Communications in Substances of Abuse
SN - 0193-0818
IS - 1
ER -