Nanotechnology and primary hemostasis: Differential effects of nanoparticles on platelet responses

María Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Eduardo Fuentes, Iván Palomo

Resultado de la investigación: Review article

  • 1 Citas

Resumen

Despite the numerous advantages offered by diverse platforms based on nanomedicine, several nanomaterials have shown significant cell toxicity that could induce chronic adverse effects on human health. Blood compatibility is one of the leading factors to consider for the design and development of nanosystems as therapeutics. Aforementioned is because systemic circulation is the gateway for most nano-drug therapeutic systems and its interactions with the blood components such as platelets could influence the maintenance of hemostasis and thrombus formation. Unfortunately, the thrombotoxicity of some nanomaterials regarding the activation/inhibition of platelets limits their biomedical applications. Additionally, the critical factors that drive those effects on platelet function are still not entirely elucidated. In this work, we describe the effect of different nanomaterials on the platelet function, its action mechanisms, and future potential as nanotherapeutics.

IdiomaEnglish
Páginas1-8
Número de páginas8
PublicaciónVascular Pharmacology
Volumen101
DOI
EstadoPublished - 1 feb 2018

Huella dactilar

Nanotechnology
Nanostructures
Hemostasis
Nanoparticles
Blood Platelets
Nanomedicine
Platelet Activation
Thrombosis
Maintenance
Health
Therapeutics
Pharmaceutical Preparations

Keywords

    ASJC Scopus subject areas

    • Physiology
    • Molecular Medicine
    • Pharmacology

    Citar esto

    Matus, María Francisca ; Vilos, Cristian ; Cisterna, Bruno A. ; Fuentes, Eduardo ; Palomo, Iván. / Nanotechnology and primary hemostasis : Differential effects of nanoparticles on platelet responses. En: Vascular Pharmacology. 2018 ; Vol. 101. pp. 1-8
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    Nanotechnology and primary hemostasis : Differential effects of nanoparticles on platelet responses. / Matus, María Francisca; Vilos, Cristian; Cisterna, Bruno A.; Fuentes, Eduardo; Palomo, Iván.

    En: Vascular Pharmacology, Vol. 101, 01.02.2018, p. 1-8.

    Resultado de la investigación: Review article

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    AU - Matus,María Francisca

    AU - Vilos,Cristian

    AU - Cisterna,Bruno A.

    AU - Fuentes,Eduardo

    AU - Palomo,Iván

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