NAD(P)H Oxidase-derived H2O2 Signals Chloride Channel Activation in Cell Volume Regulation and Cell Proliferation

Diego Varela, Felipe Simon, Ana Riveros, Finn Jørgensen, Andrés Stutzin

Resultado de la investigación: Contribución a una revistaArtículo

118 Citas (Scopus)

Resumen

Cellular swelling triggers the activation of Cl- channels (volume-sensitive outwardly rectifying (VSOR) Cl- channels) in many cell types. Ensuing regulatory volume decrease has been considered the primary function of these channels. However, Cl- channels, which share functional properties with volume-sensitive Cl- channels, have been shown to be involved in other physiological processes, including cell proliferation and apoptosis, raising the question of their physiological roles and the signal transduction pathways involved in their activation. Here we report that exogenously applied H2O2 elicited VSOR Cl - channel activation. Furthermore, activation of these channels was found to be coupled to NAD(P)H oxidase activity. Also, epidermal growth factor, known to increase H2O2 production, activated Cl - channels with properties identical to swelling-sensitive Cl - channels. It is concluded that NAD(P)H oxidase-derived H 2O2 is the common signal transducing molecule that mediates the activation of these ubiquitously expressed anion channels under a variety of physiological conditions.

Idioma originalInglés
Páginas (desde-hasta)13301-13304
Número de páginas4
PublicaciónJournal of Biological Chemistry
Volumen279
N.º14
DOI
EstadoPublicada - 2 abr 2004

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Medicina (todo)
  • Biología molecular
  • Biología celular

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