Multi-tasking by the p75 neurotrophin receptor: Sortilin things out?

Francisca C. Bronfman, Mike Fainzilber

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

71 Citas (Scopus)

Resumen

Signalling by the p75 neurotrophin receptor has been implicated in diverse neuronal responses, including increased differentiation or survival, inhibition of regeneration, and initiation of apoptotic cell death. These numerous roles are matched by, but are not yet correlated with, a multiplicity of extracellular ligands and intracellular interactors. Membrane proteins such as sortilin, a member of the Vps10p family of sorting receptors, and the glycosylphosphatidylinositol-linked Nogo receptor (NgR) and the associated adaptor lingo 1 have recently been added to the list of p75-interacting modulators. Other studies have described intramembranal cleavage of p75 and the potential nuclear targeting of cleavage fragments or of the complete receptor after it has been internalized into a putative signalling endosome. These findings suggest that some of the diversity in p75 activities might be due to differential subcellular localization and transport of p75 receptor complexes. We therefore argue that cell-biology-driven approaches are now required to make sense of p75 signalling.

Idioma originalInglés
Páginas (desde-hasta)867-871
Número de páginas5
PublicaciónEMBO Reports
Volumen5
N.º9
DOI
EstadoPublicada - 1 sep 2004
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Genética

Huella

Profundice en los temas de investigación de 'Multi-tasking by the p75 neurotrophin receptor: Sortilin things out?'. En conjunto forman una huella única.

Citar esto