mtDNA Heteroplasmy at the Core of Aging-Associated Heart Failure. An Integrative View of OXPHOS and Mitochondrial Life Cycle in Cardiac Mitochondrial Physiology

Keyphrases

• Age-related Illnesses 28%
• Aging 100%
• ATP Production 28%
• Bioenergetics 14%
• Capacity Disruption 14%
• Cardiac Cells 28%
• Cardiovascular Disease 71%
• Cell Function 14%
• Cellular Metabolism 14%
• Cellular Signaling 14%
• Double Strand 14%
• Dynamic Balance 14%
• Elderly People 42%
• First-time-in-human 14%
• Genetic Treatment 14%
• Health Costs 14%
• Heart Failure 100%
• Human History 14%
• Integrative View 100%
• Lipids 14%
• Medical Costs 14%
• Metabolic Pathway 14%
• Mitochondria 28%
• Mitochondrial Biogenesis 28%
• Mitochondrial Damage 14%
• Mitochondrial DNA 100%
• Mitochondrial Dynamics 28%
• Mitochondrial Dysfunction 28%
• Mitochondrial Fission 14%
• Mitochondrial Function 14%
• Mitochondrial Fusion 14%
• Mitochondrial Physiology 100%
• Mitochondrial Therapy 28%
• Mitophagy 42%
• Mortality Costs 14%
• MtDNA Heteroplasmy 100%
• Nutritional Intervention 14%
• Origin of Ageing 14%
• Oxidative Phosphorylation (OXPHOS) 100%
• Pharmacological Treatment 14%
• Physiopathology 14%
• Positive Impact 14%
• Productivity Costs 14%
• Reactive Oxygen Species 42%
• Sick 14%
• Signaling Pathway 14%
• World Population 14%
• World Problems 14%

Biochemistry, Genetics and Molecular Biology

• Adenosine Triphosphate 40%
• Bioenergy 20%
• Cell Function 20%
• Cell Metabolism 20%
• Dynamics 20%
• Genetics 20%
• Heteroplasmy 100%
• Life Cycle 100%
• Lipid 20%
• Mitochondrial Biogenesis 40%
• Mitochondrial Dynamics 40%
• Mitochondrial Fission 20%
• Mitochondrial Fusion 20%
• Mitochondrion 60%
• Mitophagy 60%
• Signal Transduction 40%
• Wild Type 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Adenosine Triphosphate 16%
• Cardiovascular Disease 41%
• Disease 16%
• Heart Failure 100%
• Mitochondrial DNA 100%
• Pathophysiology 8%
• Reactive Oxygen Metabolite 25%