Molecular basis of early stages of Clostridium difficile infection: Germination and colonization

Mahfuzur R. Sarker, Daniel Paredes-Sabja

Resultado de la investigación: Review article

23 Citas (Scopus)

Resumen

Clostridium difficile infections (CDIs) occur when antibiotic therapy disrupts the gastrointestinal flora, favoring infected C. difficile spores to germinate, outgrow, colonize and produce toxins. During CDI, C. difficile vegetative cells initiate the process of sporulation allowing a fraction of the spores to remain adhered to the intestinal surfaces. These spores, which are unaffected by antibiotic therapy commonly used for CDIs, then germinate, outgrow and recolonize the hosts GI tract causing relapse of CDI. Consequently, the germination and colonization processes can be considered as the earliest and most essential steps for the development as well as relapse of CDI. The aim of this review is to provide an overview on the molecular basis involved in C. difficile spore germination and colonization.

Idioma originalEnglish
Páginas (desde-hasta)933-943
Número de páginas11
PublicaciónFuture Microbiology
Volumen7
N.º8
DOI
EstadoPublished - ago 2012

Huella dactilar

Clostridium Infections
Clostridium difficile
Germination
Spores
Anti-Bacterial Agents
Recurrence
Gastrointestinal Tract

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Citar esto

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abstract = "Clostridium difficile infections (CDIs) occur when antibiotic therapy disrupts the gastrointestinal flora, favoring infected C. difficile spores to germinate, outgrow, colonize and produce toxins. During CDI, C. difficile vegetative cells initiate the process of sporulation allowing a fraction of the spores to remain adhered to the intestinal surfaces. These spores, which are unaffected by antibiotic therapy commonly used for CDIs, then germinate, outgrow and recolonize the hosts GI tract causing relapse of CDI. Consequently, the germination and colonization processes can be considered as the earliest and most essential steps for the development as well as relapse of CDI. The aim of this review is to provide an overview on the molecular basis involved in C. difficile spore germination and colonization.",
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Molecular basis of early stages of Clostridium difficile infection : Germination and colonization. / Sarker, Mahfuzur R.; Paredes-Sabja, Daniel.

En: Future Microbiology, Vol. 7, N.º 8, 08.2012, p. 933-943.

Resultado de la investigación: Review article

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AB - Clostridium difficile infections (CDIs) occur when antibiotic therapy disrupts the gastrointestinal flora, favoring infected C. difficile spores to germinate, outgrow, colonize and produce toxins. During CDI, C. difficile vegetative cells initiate the process of sporulation allowing a fraction of the spores to remain adhered to the intestinal surfaces. These spores, which are unaffected by antibiotic therapy commonly used for CDIs, then germinate, outgrow and recolonize the hosts GI tract causing relapse of CDI. Consequently, the germination and colonization processes can be considered as the earliest and most essential steps for the development as well as relapse of CDI. The aim of this review is to provide an overview on the molecular basis involved in C. difficile spore germination and colonization.

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