Modulation of host adaptive immunity by hRSV proteins

Janyra A. Espinoza, Karen Bohmwald, Pablo F. Céspedes, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis

Resultado de la investigación: Article

9 Citas (Scopus)

Resumen

Globally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sustained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology developed in hRSV-infected humans is characterized by an exacerbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interactions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this pathogen to avoid the antiviral host response.

Idioma originalEnglish
Páginas (desde-hasta)740-751
Número de páginas12
PublicaciónVirulence
Volumen5
N.º7
DOI
EstadoPublished - 2014

Huella dactilar

Human respiratory syncytial virus
Adaptive Immunity
Viruses
Proteins
Respiratory Tract Infections
Immune System
Active Immunotherapy
Virulence Factors
Antiviral Agents
Hospitalization
Vaccines
Public Health
Economics
Pathology
Lung

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Citar esto

Espinoza, J. A., Bohmwald, K., Céspedes, P. F., Riedel, C. A., Bueno, S. M., & Kalergis, A. M. (2014). Modulation of host adaptive immunity by hRSV proteins. Virulence, 5(7), 740-751. https://doi.org/10.4161/viru.32225
Espinoza, Janyra A. ; Bohmwald, Karen ; Céspedes, Pablo F. ; Riedel, Claudia A. ; Bueno, Susan M. ; Kalergis, Alexis M. / Modulation of host adaptive immunity by hRSV proteins. En: Virulence. 2014 ; Vol. 5, N.º 7. pp. 740-751.
@article{428b4a23986b4223ae0d77947e2cc2bd,
title = "Modulation of host adaptive immunity by hRSV proteins",
abstract = "Globally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sustained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology developed in hRSV-infected humans is characterized by an exacerbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interactions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this pathogen to avoid the antiviral host response.",
keywords = "Adaptive immune response, Innate immune response, Respiratory syncytial virus, Virulence proteins",
author = "Espinoza, {Janyra A.} and Karen Bohmwald and C{\'e}spedes, {Pablo F.} and Riedel, {Claudia A.} and Bueno, {Susan M.} and Kalergis, {Alexis M.}",
year = "2014",
doi = "10.4161/viru.32225",
language = "English",
volume = "5",
pages = "740--751",
journal = "Virulence",
issn = "2150-5594",
publisher = "Landes Bioscience",
number = "7",

}

Espinoza, JA, Bohmwald, K, Céspedes, PF, Riedel, CA, Bueno, SM & Kalergis, AM 2014, 'Modulation of host adaptive immunity by hRSV proteins', Virulence, vol. 5, n.º 7, pp. 740-751. https://doi.org/10.4161/viru.32225

Modulation of host adaptive immunity by hRSV proteins. / Espinoza, Janyra A.; Bohmwald, Karen; Céspedes, Pablo F.; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.

En: Virulence, Vol. 5, N.º 7, 2014, p. 740-751.

Resultado de la investigación: Article

TY - JOUR

T1 - Modulation of host adaptive immunity by hRSV proteins

AU - Espinoza, Janyra A.

AU - Bohmwald, Karen

AU - Céspedes, Pablo F.

AU - Riedel, Claudia A.

AU - Bueno, Susan M.

AU - Kalergis, Alexis M.

PY - 2014

Y1 - 2014

N2 - Globally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sustained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology developed in hRSV-infected humans is characterized by an exacerbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interactions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this pathogen to avoid the antiviral host response.

AB - Globally, the human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infections (LRTIs) in infants and children younger than 2 years old. Furthermore, the number of hospitalizations due to LRTIs has shown a sustained increase every year due to the lack of effective vaccines against hRSV. Thus, this virus remains as a major public health and economic burden worldwide. The lung pathology developed in hRSV-infected humans is characterized by an exacerbated inflammatory and Th2 immune response. In order to rationally design new vaccines and therapies against this virus, several studies have focused in elucidating the interactions between hRSV virulence factors and the host immune system. Here, we discuss the main features of hRSV biology, the processes involved in virus recognition by the immune system and the most relevant mechanisms used by this pathogen to avoid the antiviral host response.

KW - Adaptive immune response

KW - Innate immune response

KW - Respiratory syncytial virus

KW - Virulence proteins

UR - http://www.scopus.com/inward/record.url?scp=84908233747&partnerID=8YFLogxK

U2 - 10.4161/viru.32225

DO - 10.4161/viru.32225

M3 - Article

C2 - 25513775

AN - SCOPUS:84908233747

VL - 5

SP - 740

EP - 751

JO - Virulence

JF - Virulence

SN - 2150-5594

IS - 7

ER -

Espinoza JA, Bohmwald K, Céspedes PF, Riedel CA, Bueno SM, Kalergis AM. Modulation of host adaptive immunity by hRSV proteins. Virulence. 2014;5(7):740-751. https://doi.org/10.4161/viru.32225