Modulating the function of the immune system by thyroid hormones and thyrotropin

Evelyn L. Jara, Natalia Muñoz-Durango, Carolina Llanos, Carlos Fardella, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

60 Citas (Scopus)

Resumen

Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections. Under these conditions, TH therapy could contribute to restoring normal physiological functions. Here we discuss the effects of THs and thyroid stimulating hormone (TSH) on the immune system and the contribution to inflammation and pathogen clearance, as well as the consequences of thyroid pathologies over the function of the immune system.

Idioma originalInglés
Páginas (desde-hasta)76-83
Número de páginas8
PublicaciónImmunology Letters
Volumen184
DOI
EstadoPublicada - 1 abr. 2017

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Inmunología

Huella

Profundice en los temas de investigación de 'Modulating the function of the immune system by thyroid hormones and thyrotropin'. En conjunto forman una huella única.

Citar esto