Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

Paula I. Rodas, Doris Pérez, Claudia Jauffret, Yaquelin González, Carolina Carreño, Cecilia V. Tapia, Eduardo Osorio, Luis A. Velasquez, Myron Christodoulides

Resultado de la investigación: Contribución a una revistaArtículo

4 Citas (Scopus)

Resumen

Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

Idioma originalInglés
Páginas (desde-hasta)452-455
Número de páginas4
PublicaciónJournal of Infectious Diseases
Volumen215
N.º3
DOI
EstadoPublicada - 1 ene 2017

Áreas temáticas de ASJC Scopus

  • Inmulogía y alergología
  • Enfermedades infecciosas

Huella Profundice en los temas de investigación de 'Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae'. En conjunto forman una huella única.

  • Citar esto

    Rodas, P. I., Pérez, D., Jauffret, C., González, Y., Carreño, C., Tapia, C. V., Osorio, E., Velasquez, L. A., & Christodoulides, M. (2017). Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae. Journal of Infectious Diseases, 215(3), 452-455. https://doi.org/10.1093/infdis/jiw568