Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

Paula I. Rodas, Doris Pérez, Claudia Jauffret, Yaquelin González, Carolina Carreño, Cecilia V. Tapia, Eduardo Osorio, Luis A. Velasquez, Myron Christodoulides

Resultado de la investigación: Article

4 Citas (Scopus)

Resumen

Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

Idioma originalEnglish
Páginas (desde-hasta)452-455
Número de páginas4
PublicaciónJournal of Infectious Diseases
Volumen215
N.º3
DOI
EstadoPublished - 1 ene 2017

Huella dactilar

Fallopian Tubes
Neisseria gonorrhoeae
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Epithelial Cells
Matrix Metalloproteinases
Cicatrix
Secreted Matrix Metalloproteinases
Infection
Matrix Metalloproteinase 8
Matrix Metalloproteinase 3
Extracellular Matrix
Mucous Membrane
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Citar esto

Rodas, Paula I. ; Pérez, Doris ; Jauffret, Claudia ; González, Yaquelin ; Carreño, Carolina ; Tapia, Cecilia V. ; Osorio, Eduardo ; Velasquez, Luis A. ; Christodoulides, Myron. / Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae. En: Journal of Infectious Diseases. 2017 ; Vol. 215, N.º 3. pp. 452-455.
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abstract = "Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.",
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Rodas, PI, Pérez, D, Jauffret, C, González, Y, Carreño, C, Tapia, CV, Osorio, E, Velasquez, LA & Christodoulides, M 2017, 'Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae', Journal of Infectious Diseases, vol. 215, n.º 3, pp. 452-455. https://doi.org/10.1093/infdis/jiw568

Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae. / Rodas, Paula I.; Pérez, Doris; Jauffret, Claudia; González, Yaquelin; Carreño, Carolina; Tapia, Cecilia V.; Osorio, Eduardo; Velasquez, Luis A.; Christodoulides, Myron.

En: Journal of Infectious Diseases, Vol. 215, N.º 3, 01.01.2017, p. 452-455.

Resultado de la investigación: Article

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T1 - Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

AU - Rodas, Paula I.

AU - Pérez, Doris

AU - Jauffret, Claudia

AU - González, Yaquelin

AU - Carreño, Carolina

AU - Tapia, Cecilia V.

AU - Osorio, Eduardo

AU - Velasquez, Luis A.

AU - Christodoulides, Myron

PY - 2017/1/1

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N2 - Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

AB - Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.

KW - Extracellular matrix

KW - Human Fallopian tube epithelial cells

KW - Matrix metalloproteinases

KW - Neisseria gonorrhoeae

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