Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models

Rodrigo Assar, Martín A. Montecino, Alejandro Maass, David J. Sherman

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological system. In this article we formalize the use of hybrid systems as a tool to model this kind of biological behavior. A modeling scheme called strong switches is proposed. It allows one to take into account both minor adjustments to the coefficients of a continuous model, and, more interestingly, large-scale changes to the structure of the model. We illustrate the proposed methodology with two applications: acclimatization in wine fermentation kinetics, and acclimatization of osteo-adipo differentiation system linking stimulus signals to bone mass.

Idioma originalInglés
Páginas (desde-hasta)43-53
Número de páginas11
PublicaciónBioSystems
Volumen121
DOI
EstadoPublicada - jul. 2014

Áreas temáticas de ASJC Scopus

  • Estadística y probabilidad
  • Modelización y simulación
  • Bioquímica, genética y biología molecular (todo)
  • Matemáticas aplicadas

Huella

Profundice en los temas de investigación de 'Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models'. En conjunto forman una huella única.

Citar esto