TY - JOUR
T1 - Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment
AU - Clemente-Suárez, Vicente Javier
AU - Martín-Rodríguez, Alexandra
AU - Yáñez-Sepúlveda, Rodrigo
AU - Tornero-Aguilera, José Francisco
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.
AB - Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.
KW - cancer
KW - cell death
KW - disease diagnosis
KW - disease treatment
KW - metabolic disorders
KW - mitochondrial transfer
KW - neurodegenerative diseases
UR - http://www.scopus.com/inward/record.url?scp=85160380100&partnerID=8YFLogxK
U2 - 10.3390/ijms24108848
DO - 10.3390/ijms24108848
M3 - Review article
C2 - 37240194
AN - SCOPUS:85160380100
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 10
M1 - 8848
ER -