Mitochondrial Dysfunction in Skeletal Muscle Pathologies

Johanna Abrigo, Felipe Simon, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

14 Citas (Scopus)

Resumen

Several molecular mechanisms are involved in the regulation of skeletal muscle function. Among them, mitochondrial activity can be identified. The mitochondria is an important and essential organelle in the skeletal muscle that is involved in metabolic regulation and ATP production, which are two key elements of muscle contractibility and plasticity. Thus, in this review, we present the critical and recent antecedents regarding the mechanisms through which mitochondrial dysfunction can be involved in the generation and development of skeletal muscle pathologies, its contribution to detrimental functioning in skeletal muscle and its crosstalk with other typical signaling pathways related to muscle diseases. In addition, an update on the development of new strategies with therapeutic potential to inhibit the deleterious impact of mitochondrial dysfunction in skeletal muscle is discussed.

Idioma originalInglés
Páginas (desde-hasta)536-546
Número de páginas11
PublicaciónCurrent protein & peptide science
Volumen20
N.º6
DOI
EstadoPublicada - 1 ene 2019

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

Huella

Profundice en los temas de investigación de 'Mitochondrial Dysfunction in Skeletal Muscle Pathologies'. En conjunto forman una huella única.

Citar esto