Mitochondria in structural and functional cardiac remodeling

Natalia Torrealba, Pablo Aranguiz, Camila Alonso, Beverly A. Rothermel, Sergio Lavandero

Producción científica: Contribución a los tipos de informe/libroCapítulorevisión exhaustiva

55 Citas (Scopus)


The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to excretory organs. When facing either a physiological or pathological increase in cardiac demand, the heart undergoes structural and functional remodeling as a means of adapting to increased workload. These adaptive responses can include changes in gene expression, protein composition, and structure of sub-cellular organelles involved in energy production and metabolism. Mitochondria are essential for cardiac function, as they supply the ATP necessary to support continuous cycles of contraction and relaxation. In addition, mitochondria carry out other important processes, including synthesis of essential cellular components, calcium buffering, and initiation of cell death signals. Not surprisingly, mitochondrial dysfunction has been linked to several cardiovascular disorders, including hypertension, cardiac hypertrophy, ischemia/reperfusion and heart failure. The present chapter will discuss how changes in mitochondrial cristae structure, fusion/fission dynamics, fatty acid oxidation, ATP production, and the generation of reactive oxygen species might impact cardiac structure and function, particularly in the context of pathological hypertrophy and fibrotic response. In addition, the mechanistic role of mitochondria in autophagy and programmed cell death of cardiomyocytes will be addressed. Here we will also review strategies to improve mitochondrial function and discuss their cardioprotective potential.

Idioma originalInglés
Título de la publicación alojadaAdvances in Experimental Medicine and Biology
EditorialSpringer New York LLC
Número de páginas30
EstadoPublicada - 1 may. 2017

Serie de la publicación

NombreAdvances in Experimental Medicine and Biology
ISSN (versión impresa)0065-2598
ISSN (versión digital)2214-8019

Áreas temáticas de ASJC Scopus

  • Bioquímica, Genética y Biología Molecular General


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