TY - JOUR
T1 - Mitochondria and Brain Disease
T2 - A Comprehensive Review of Pathological Mechanisms and Therapeutic Opportunities
AU - Clemente-Suárez, Vicente Javier
AU - Redondo-Flórez, Laura
AU - Beltrán-Velasco, Ana Isabel
AU - Ramos-Campo, Domingo Jesús
AU - Belinchón-deMiguel, Pedro
AU - Martinez-Guardado, Ismael
AU - Dalamitros, Athanasios A.
AU - Yáñez-Sepúlveda, Rodrigo
AU - Martín-Rodríguez, Alexandra
AU - Tornero-Aguilera, José Francisco
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9
Y1 - 2023/9
N2 - Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.
AB - Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated in the pathogenesis of various brain diseases, including neurodegenerative disorders, stroke, and psychiatric illnesses. This review paper provides a comprehensive overview of the intricate relationship between mitochondria and brain disease, focusing on the underlying pathological mechanisms and exploring potential therapeutic opportunities. The review covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, mitochondrial dynamics, calcium dysregulation, and reactive oxygen species generation in the context of brain disease. Additionally, it discusses emerging strategies targeting mitochondrial dysfunction, including mitochondrial protective agents, metabolic modulators, and gene therapy approaches. By critically analysing the existing literature and recent advancements, this review aims to enhance our understanding of the multifaceted role of mitochondria in brain disease and shed light on novel therapeutic interventions.
KW - brain disease
KW - mitochondria
KW - mitochondrial DNA mutations
KW - mitochondrial dynamics
KW - mitochondrial protective agents
KW - neurodegenerative disorders
KW - oxidative phosphorylation
KW - reactive oxygen species
UR - http://www.scopus.com/inward/record.url?scp=85172479847&partnerID=8YFLogxK
U2 - 10.3390/biomedicines11092488
DO - 10.3390/biomedicines11092488
M3 - Review article
AN - SCOPUS:85172479847
SN - 2227-9059
VL - 11
JO - Biomedicines
JF - Biomedicines
IS - 9
M1 - 2488
ER -