Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435

Pertti L.A. Lähteenmäki, Soledad Diaz, Patricia Miranda, Horacio Croxatto, Pekka Lähteenmäki

Resultado de la investigación: Contribución a una revistaArtículo

17 Citas (Scopus)

Resumen

A subcutaneous contraceptive capsule releasing progestin ST-1435 was used by 6 breast-feeding women. One to three paired milk and plasma samples were collected over a one-month period and the concentrations of ST-1435 were determined by radioimmunoassay. An improved and sensitive method for determination of ST-1435 in milk was developed. A column chromatographic purification of milk prior to radioimmunoassay decreased the blank and improved sensitivity. The average plasma concentration of ST-1435 was 62 ± 20 pg/ml (mean ± SD). The average milk concentration of ST-1435 was 38 pg/ml (ranging from 7 to 73 pg/ml), while the average milk to plasma ratio was 0.60 (ranging from 0.25 to 0.91). There was a significant correlation between ST-1435 concentrations in breast milk and plasma, indicating that the concentration in plasma is the major determinant for the amount of ST-1435 excreted into milk. Since studies with this drug have shown good contraceptive efficacy and low bioavailability after oral intake, ST-1435 is a good candidate for lactational contraception.

Idioma originalInglés
Páginas (desde-hasta)555-562
Número de páginas8
PublicaciónContraception
Volumen42
N.º5
DOI
EstadoPublicada - 1 ene 1990

Áreas temáticas de ASJC Scopus

  • Medicina reproductiva
  • Ginecología y obstetricia

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