Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435

Pertti L.A. Lähteenmäki, Soledad Diaz, Patricia Miranda, Horacio Croxatto, Pekka Lähteenmäki

Resultado de la investigación: Article

17 Citas (Scopus)

Resumen

A subcutaneous contraceptive capsule releasing progestin ST-1435 was used by 6 breast-feeding women. One to three paired milk and plasma samples were collected over a one-month period and the concentrations of ST-1435 were determined by radioimmunoassay. An improved and sensitive method for determination of ST-1435 in milk was developed. A column chromatographic purification of milk prior to radioimmunoassay decreased the blank and improved sensitivity. The average plasma concentration of ST-1435 was 62 ± 20 pg/ml (mean ± SD). The average milk concentration of ST-1435 was 38 pg/ml (ranging from 7 to 73 pg/ml), while the average milk to plasma ratio was 0.60 (ranging from 0.25 to 0.91). There was a significant correlation between ST-1435 concentrations in breast milk and plasma, indicating that the concentration in plasma is the major determinant for the amount of ST-1435 excreted into milk. Since studies with this drug have shown good contraceptive efficacy and low bioavailability after oral intake, ST-1435 is a good candidate for lactational contraception.

Idioma originalEnglish
Páginas (desde-hasta)555-562
Número de páginas8
PublicaciónContraception
Volumen42
N.º5
DOI
EstadoPublished - 1 ene 1990

Huella dactilar

Progestins
Milk
Contraceptive Agents
Radioimmunoassay
ST 1435
Human Milk
Breast Feeding
Contraception
Biological Availability
Capsules
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Citar esto

Lähteenmäki, Pertti L.A. ; Diaz, Soledad ; Miranda, Patricia ; Croxatto, Horacio ; Lähteenmäki, Pekka. / Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435. En: Contraception. 1990 ; Vol. 42, N.º 5. pp. 555-562.
@article{a164cdd4b55746c894ac8092004db80c,
title = "Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435",
abstract = "A subcutaneous contraceptive capsule releasing progestin ST-1435 was used by 6 breast-feeding women. One to three paired milk and plasma samples were collected over a one-month period and the concentrations of ST-1435 were determined by radioimmunoassay. An improved and sensitive method for determination of ST-1435 in milk was developed. A column chromatographic purification of milk prior to radioimmunoassay decreased the blank and improved sensitivity. The average plasma concentration of ST-1435 was 62 ± 20 pg/ml (mean ± SD). The average milk concentration of ST-1435 was 38 pg/ml (ranging from 7 to 73 pg/ml), while the average milk to plasma ratio was 0.60 (ranging from 0.25 to 0.91). There was a significant correlation between ST-1435 concentrations in breast milk and plasma, indicating that the concentration in plasma is the major determinant for the amount of ST-1435 excreted into milk. Since studies with this drug have shown good contraceptive efficacy and low bioavailability after oral intake, ST-1435 is a good candidate for lactational contraception.",
author = "L{\"a}hteenm{\"a}ki, {Pertti L.A.} and Soledad Diaz and Patricia Miranda and Horacio Croxatto and Pekka L{\"a}hteenm{\"a}ki",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0010-7824(90)90082-7",
language = "English",
volume = "42",
pages = "555--562",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "5",

}

Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435. / Lähteenmäki, Pertti L.A.; Diaz, Soledad; Miranda, Patricia; Croxatto, Horacio; Lähteenmäki, Pekka.

En: Contraception, Vol. 42, N.º 5, 01.01.1990, p. 555-562.

Resultado de la investigación: Article

TY - JOUR

T1 - Milk and plasma concentrations of the progestin ST-1435 in women treated parenterally with ST-1435

AU - Lähteenmäki, Pertti L.A.

AU - Diaz, Soledad

AU - Miranda, Patricia

AU - Croxatto, Horacio

AU - Lähteenmäki, Pekka

PY - 1990/1/1

Y1 - 1990/1/1

N2 - A subcutaneous contraceptive capsule releasing progestin ST-1435 was used by 6 breast-feeding women. One to three paired milk and plasma samples were collected over a one-month period and the concentrations of ST-1435 were determined by radioimmunoassay. An improved and sensitive method for determination of ST-1435 in milk was developed. A column chromatographic purification of milk prior to radioimmunoassay decreased the blank and improved sensitivity. The average plasma concentration of ST-1435 was 62 ± 20 pg/ml (mean ± SD). The average milk concentration of ST-1435 was 38 pg/ml (ranging from 7 to 73 pg/ml), while the average milk to plasma ratio was 0.60 (ranging from 0.25 to 0.91). There was a significant correlation between ST-1435 concentrations in breast milk and plasma, indicating that the concentration in plasma is the major determinant for the amount of ST-1435 excreted into milk. Since studies with this drug have shown good contraceptive efficacy and low bioavailability after oral intake, ST-1435 is a good candidate for lactational contraception.

AB - A subcutaneous contraceptive capsule releasing progestin ST-1435 was used by 6 breast-feeding women. One to three paired milk and plasma samples were collected over a one-month period and the concentrations of ST-1435 were determined by radioimmunoassay. An improved and sensitive method for determination of ST-1435 in milk was developed. A column chromatographic purification of milk prior to radioimmunoassay decreased the blank and improved sensitivity. The average plasma concentration of ST-1435 was 62 ± 20 pg/ml (mean ± SD). The average milk concentration of ST-1435 was 38 pg/ml (ranging from 7 to 73 pg/ml), while the average milk to plasma ratio was 0.60 (ranging from 0.25 to 0.91). There was a significant correlation between ST-1435 concentrations in breast milk and plasma, indicating that the concentration in plasma is the major determinant for the amount of ST-1435 excreted into milk. Since studies with this drug have shown good contraceptive efficacy and low bioavailability after oral intake, ST-1435 is a good candidate for lactational contraception.

UR - http://www.scopus.com/inward/record.url?scp=0025609408&partnerID=8YFLogxK

U2 - 10.1016/0010-7824(90)90082-7

DO - 10.1016/0010-7824(90)90082-7

M3 - Article

VL - 42

SP - 555

EP - 562

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 5

ER -