Microbial transformation of marine halogenated sesquiterpenes

Aurelio San Martin; Juana Rovirosa; Alvaro Carrasco; Silvia Orejarena; Jorge Soto-Delgado; Renato Contreras; M. Cristina Chamy

Microbial transformation of marine halogenated sesquiterpenes

Aurelio San Martin, Juana Rovirosa, Alvaro Carrasco, Silvia Orejarena, Jorge Soto-Delgado, Renato Contreras, M. Cristina Chamy

Facultad Ciencias Exactas

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

5 Citas (Scopus)

Resumen

The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.

Idioma original	Inglés
Páginas (desde-hasta)	1859-1864
Número de páginas	6
Publicación	Natural Product Communications
Volumen	5
N.º	12
Estado	Publicada - 2010

Áreas temáticas de ASJC Scopus

Farmacología
Descubrimiento de medicamentos
Botánica
Medicina complementaria y alternativa

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@article{844e267525034360afcebf907ad7a5d0,

title = "Microbial transformation of marine halogenated sesquiterpenes",

abstract = "The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus n{\'i}ger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.",

keywords = "Biotransformation, Laurencia claviformis, Mucor plumbeus, Pacifenol, Pacifidiene",

author = "{San Martin}, Aurelio and Juana Rovirosa and Alvaro Carrasco and Silvia Orejarena and Jorge Soto-Delgado and Renato Contreras and Chamy, {M. Cristina}",

year = "2010",

language = "English",

volume = "5",

pages = "1859--1864",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

number = "12",

}

TY - JOUR

T1 - Microbial transformation of marine halogenated sesquiterpenes

AU - San Martin, Aurelio

AU - Rovirosa, Juana

AU - Carrasco, Alvaro

AU - Orejarena, Silvia

AU - Soto-Delgado, Jorge

AU - Contreras, Renato

AU - Chamy, M. Cristina

PY - 2010

Y1 - 2010

N2 - The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.

AB - The sesquiterpene pacifenol is one of the main constituents of the red alga Laurencia claviformis. Earlier work on the semisynthetic derivatives of pacifenol afforded a series of halogenated sesquiterpenes. The aim of the present work was to obtain new hydroxylated derivatives of halogenated sesquiterpenes by means of microbial transformation using Aspergillus níger, Gibberella fujikuroi and Mucor plumbeus. The best results were obtained with M. plumbeus. The microbiological transformation by M. plumbeus of pacifenol, and two semisynthetic derivatives, is described. The structures of the new compounds obtained were determined by spectroscopic means.

KW - Biotransformation

KW - Laurencia claviformis

KW - Mucor plumbeus

KW - Pacifenol

KW - Pacifidiene

UR - http://www.scopus.com/inward/record.url?scp=78751514014&partnerID=8YFLogxK

M3 - Article

C2 - 21299107

AN - SCOPUS:78751514014

SN - 1934-578X

VL - 5

SP - 1859

EP - 1864

JO - Natural Product Communications

JF - Natural Product Communications

IS - 12

ER -

Microbial transformation of marine halogenated sesquiterpenes

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