Methylation of histone H3 lysine 9 occurs during translation

Carlos Rivera, Francisco Saavedra, Francisca Alvarez, César Díaz-Celis, Valentina Ugalde, Jianhua Li, Ignasi Forné, Zachary A. Gurard-Levin, Geneviève Almouzni, Axel Imhof, Alejandra Loyola

Resultado de la investigación: Article

20 Citas (Scopus)

Resumen

Histone post-translational modifications are key contributors to chromatin structure and function, and participate in the maintenance of genome stability. Understanding the establishment and maintenance of these marks, along with their misregulation in pathologies is thus a major focus in the field. While we have learned a great deal about the enzymes regulating histone modifications on nucleosomal histones, much less is known about the mechanisms establishing modifications on soluble newly synthesized histones. This includes methylation of lysine 9 on histone H3 (H3K9), a mark that primes the formation of heterochromatin, a critical chromatin landmark for genome stability. Here, we report that H3K9 mono- and dimethylation is imposed during translation by the methyltransferase SetDB1. We discuss the importance of these results in the context of heterochromatin establishment and maintenance and new therapeutic opportunities in pathologies where heterochromatin is perturbed.

Idioma originalEnglish
Páginas (desde-hasta)9097-9106
Número de páginas10
PublicaciónNucleic Acids Research
Volumen43
N.º19
DOI
EstadoPublished - 30 oct 2015

Huella dactilar

Histones
Methylation
Lysine
Heterochromatin
Genomic Instability
Maintenance
Chromatin
Histone Code
Pathology
Methyltransferases
Post Translational Protein Processing
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Genetics

Citar esto

Rivera, C., Saavedra, F., Alvarez, F., Díaz-Celis, C., Ugalde, V., Li, J., ... Loyola, A. (2015). Methylation of histone H3 lysine 9 occurs during translation. Nucleic Acids Research, 43(19), 9097-9106. https://doi.org/10.1093/nar/gkv929
Rivera, Carlos ; Saavedra, Francisco ; Alvarez, Francisca ; Díaz-Celis, César ; Ugalde, Valentina ; Li, Jianhua ; Forné, Ignasi ; Gurard-Levin, Zachary A. ; Almouzni, Geneviève ; Imhof, Axel ; Loyola, Alejandra. / Methylation of histone H3 lysine 9 occurs during translation. En: Nucleic Acids Research. 2015 ; Vol. 43, N.º 19. pp. 9097-9106.
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Rivera, C, Saavedra, F, Alvarez, F, Díaz-Celis, C, Ugalde, V, Li, J, Forné, I, Gurard-Levin, ZA, Almouzni, G, Imhof, A & Loyola, A 2015, 'Methylation of histone H3 lysine 9 occurs during translation', Nucleic Acids Research, vol. 43, n.º 19, pp. 9097-9106. https://doi.org/10.1093/nar/gkv929

Methylation of histone H3 lysine 9 occurs during translation. / Rivera, Carlos; Saavedra, Francisco; Alvarez, Francisca; Díaz-Celis, César; Ugalde, Valentina; Li, Jianhua; Forné, Ignasi; Gurard-Levin, Zachary A.; Almouzni, Geneviève; Imhof, Axel; Loyola, Alejandra.

En: Nucleic Acids Research, Vol. 43, N.º 19, 30.10.2015, p. 9097-9106.

Resultado de la investigación: Article

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AU - Alvarez, Francisca

AU - Díaz-Celis, César

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AU - Li, Jianhua

AU - Forné, Ignasi

AU - Gurard-Levin, Zachary A.

AU - Almouzni, Geneviève

AU - Imhof, Axel

AU - Loyola, Alejandra

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Rivera C, Saavedra F, Alvarez F, Díaz-Celis C, Ugalde V, Li J y otros. Methylation of histone H3 lysine 9 occurs during translation. Nucleic Acids Research. 2015 oct 30;43(19):9097-9106. https://doi.org/10.1093/nar/gkv929