Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier

A. C. Sintov, C. Velasco-Aguirre, E. Gallardo-Toledo, E. Araya, M. J. Kogan

Resultado de la investigación: Chapter

15 Citas (Scopus)

Resumen

Metal nanoparticles have been proposed as a carrier and a therapeutic agent in biomedical field because of their unique physiochemical properties. Due to these physicochemical properties, they can be used in different fields of biomedicine. In relation to this, plasmonic nanoparticles can be used for detection and photothermal destruction of tumor cells or toxic protein aggregates, and magnetic iron nanoparticles can be used for imaging and for hyperthermia of tumor cells. In addition, both therapy and imaging can be combined in one nanoparticle system, in a process called theranostics. Metal nanoparticles can be synthesized to modulate their size and shape, and conjugated with different ligands, which allow their application in drug delivery, diagnostics, and treatment of central nervous system diseases. This review is focused on the potential applications of metal nanoparticles and their capability to circumvent the blood–brain barrier (BBB). Although many articles have demonstrated delivery of metal nanoparticles to the brain by crossing the BBB after systemic administration, the percentage of the injected dose that reaches this organ is low in comparison to others, especially the liver and spleen. In connection with this drawback, we elaborate the architecture of the BBB and review possible mechanisms to cross this barrier by engineered nanoparticles. The potential uses of metal nanoparticles for treatment of disorders as well as related neurotoxicological considerations are also discussed. Finally, we bring up for discussion a direct and relatively simpler solution to the problem. We discuss this in detail after having proposed the use of the intranasal administration route as a way to circumvent the BBB. This route has not been extensively studied yet for metal nanoparticles, although it could be used as a research tool for mechanistic understanding and toxicity as well as an added value for medical practice.

Idioma originalEnglish
Título de la publicación alojadaNanotechnology and the Brain, 2016
EditorialAcademic Press Inc.
Páginas199-227
Número de páginas29
ISBN (versión impresa)9780128046364
DOI
EstadoPublished - 1 ene 2016

Serie de la publicación

NombreInternational Review of Neurobiology
Volumen130
ISSN (versión impresa)0074-7742
ISSN (versión digital)2162-5514

Huella dactilar

Metal Nanoparticles
Nanoparticles
Intranasal Administration
Poisons
Central Nervous System Diseases
Therapeutics
Neoplasms
Fever
Spleen
Iron
Ligands
Liver
Brain
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Citar esto

Sintov, A. C., Velasco-Aguirre, C., Gallardo-Toledo, E., Araya, E., & Kogan, M. J. (2016). Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016 (pp. 199-227). (International Review of Neurobiology; Vol. 130). Academic Press Inc.. https://doi.org/10.1016/bs.irn.2016.06.007
Sintov, A. C. ; Velasco-Aguirre, C. ; Gallardo-Toledo, E. ; Araya, E. ; Kogan, M. J. / Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. Nanotechnology and the Brain, 2016. Academic Press Inc., 2016. pp. 199-227 (International Review of Neurobiology).
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Sintov, AC, Velasco-Aguirre, C, Gallardo-Toledo, E, Araya, E & Kogan, MJ 2016, Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016. International Review of Neurobiology, vol. 130, Academic Press Inc., pp. 199-227. https://doi.org/10.1016/bs.irn.2016.06.007

Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. / Sintov, A. C.; Velasco-Aguirre, C.; Gallardo-Toledo, E.; Araya, E.; Kogan, M. J.

Nanotechnology and the Brain, 2016. Academic Press Inc., 2016. p. 199-227 (International Review of Neurobiology; Vol. 130).

Resultado de la investigación: Chapter

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AU - Kogan, M. J.

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Sintov AC, Velasco-Aguirre C, Gallardo-Toledo E, Araya E, Kogan MJ. Metal Nanoparticles as Targeted Carriers Circumventing the Blood–Brain Barrier. En Nanotechnology and the Brain, 2016. Academic Press Inc. 2016. p. 199-227. (International Review of Neurobiology). https://doi.org/10.1016/bs.irn.2016.06.007