Mesoporous mixed oxides prepared by hard template methodology as novel drug delivery carriers for methotrexate

Estefanía Vélez-Peña, Ruddy Morales, Carlos Reyes-Escobar, Cecilia C. Torres, Marcia Avello, Kelly P. Marrugo, Joaquín Manzo-Merino, Joel B. Alderete, Cristian H. Campos

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Non-silica-based metal oxide nanomaterials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of chemotherapeutic drugs providing an enhanced biocompatibility in compares with silica-based nanocarriers. Herein, mesoporous materials were synthesized from hard-templated lanthanum-manganese (NC–LaMn) and barium-titanium (NC–BaTi) mixed oxides are evaluated as new drug nanocarriers, using methotrexate (MTX) as a model therapeutic compound. The SBA-15 material was used as a hard template to assist the sol-gel synthesis to provide the corresponding nanocarriers. The templated nanomaterials were characterized by X-ray diffraction (XRD), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), N2 adsorption-desorption isotherms, and thermogravimetric analysis (TGA), which revealed remarkably high surface area (SBET ∼ 180 m2/g) and displayed mean nanoparticle sizes ∼ 700–1100 nm. The NC-LaMn and NC-BaTi carriers showed a loading efficiency of 47.2 mg/g and 70.1 mg/g for the encapsulation of MTX, respectively. Both mixed-metal oxides showed higher drug uptake than SBA-15 (22.6 mg/g) due to the higher alkalinity of the carriers, which promoted host-guest affinity by acid/base interactions. The carriers showed pH-dependent release of MTX and adjust their release profile at Korsmeyer-Peppas kinetics model. The release at pH = 5.5 for both mixed-oxides (kNC-LaMn 0.077 and kNC-BaTi 0.068) was faster than that at pH = 7.4 for (kNC-LaMn 0.022 and kNC-BaTi 0.019). Additionally, hemolysis and cell viability assays indicated that NC-BaTi was a biocompatible nanocarrier with no toxicity, whereas NC-LaMn was toxic even at low dosages for both red blood and HeLa cells. The results suggested that the synthesized NC-BaTi metal oxide had great potential as a nanocarrier in cancer therapy with optimal loading content and sustained release of MTX.

Idioma originalInglés
Número de artículo103483
PublicaciónJournal of Drug Delivery Science and Technology
Volumen73
DOI
EstadoPublicada - jul. 2022

Áreas temáticas de ASJC Scopus

  • Ciencias farmacéuticas

Huella

Profundice en los temas de investigación de 'Mesoporous mixed oxides prepared by hard template methodology as novel drug delivery carriers for methotrexate'. En conjunto forman una huella única.

Citar esto