Mechanisms of tau self-aggregation and neurotoxicity

G. Farías, A. Cornejo, J. Jiménez, L. Guzmán, R. B. Maccioni

Resultado de la investigación: Article

32 Citas (Scopus)

Resumen

Pathological tau protein aggregates can be found in brain of patients with some of the neurodegenerative diseases collectively known as tauopathies, which include Alzheimer's disease (AD). Since tau post-translational modifications including phosphorylations, glycosylations, truncation and the subsequent aggregation in oligomers, paired helical filaments (PHFs) and neurofibrillary tangles (NFTs), correlate with cognitive impairment and neurodegeneration in AD, a pathogenic role for tau and its modifications has been raised. Here we summarize the current status of knowledge about tau modifications under pathologic conditions and the evidence supporting neurotoxic - or neuroprotective - roles of the diverse forms of modified and aggregated tau. Finally, we analyze the structural and functional tau alterations found in different tauopathies and how these modifications are related to the pathophysiologic mechanisms of neurodegeneration.

Idioma originalEnglish
Páginas (desde-hasta)608-614
Número de páginas7
PublicaciónCurrent Alzheimer Research
Volumen8
N.º6
DOI
EstadoPublished - 1 sep 2011

Huella dactilar

Tauopathies
Alzheimer Disease
tau Proteins
Neurofibrillary Tangles
Post Translational Protein Processing
Glycosylation
Neurodegenerative Diseases
Phosphorylation
Brain
Protein Aggregates
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Citar esto

Farías, G. ; Cornejo, A. ; Jiménez, J. ; Guzmán, L. ; Maccioni, R. B. / Mechanisms of tau self-aggregation and neurotoxicity. En: Current Alzheimer Research. 2011 ; Vol. 8, N.º 6. pp. 608-614.
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Farías, G, Cornejo, A, Jiménez, J, Guzmán, L & Maccioni, RB 2011, 'Mechanisms of tau self-aggregation and neurotoxicity', Current Alzheimer Research, vol. 8, n.º 6, pp. 608-614. https://doi.org/10.2174/156720511796717258

Mechanisms of tau self-aggregation and neurotoxicity. / Farías, G.; Cornejo, A.; Jiménez, J.; Guzmán, L.; Maccioni, R. B.

En: Current Alzheimer Research, Vol. 8, N.º 6, 01.09.2011, p. 608-614.

Resultado de la investigación: Article

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