Resumen
Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 1750-1752 |
| Número de páginas | 3 |
| Publicación | Journal of the Chilean Chemical Society |
| Volumen | 58 |
| N.º | 2 |
| DOI | |
| Estado | Published - 1 ene 2013 |
Huella dactilar
ASJC Scopus subject areas
- Chemistry(all)
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Lichens : Might be considered as a source of gastroprotective molecules? / Sepulveda, Beatriz; Chamy, Maria Cristina; Piovano, Marisa; Areche, Carlos.
En: Journal of the Chilean Chemical Society, Vol. 58, N.º 2, 01.01.2013, p. 1750-1752.Resultado de la investigación: Article
TY - JOUR
T1 - Lichens
T2 - Might be considered as a source of gastroprotective molecules?
AU - Sepulveda, Beatriz
AU - Chamy, Maria Cristina
AU - Piovano, Marisa
AU - Areche, Carlos
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
AB - Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.
KW - Depside
KW - Depsidone
KW - Gastric ulcer
KW - Lichens
UR - http://www.scopus.com/inward/record.url?scp=84884177325&partnerID=8YFLogxK
U2 - 10.4067/S0717-97072013000200024
DO - 10.4067/S0717-97072013000200024
M3 - Article
AN - SCOPUS:84884177325
VL - 58
SP - 1750
EP - 1752
JO - Journal of the Chilean Chemical Society
JF - Journal of the Chilean Chemical Society
SN - 0717-9324
IS - 2
ER -