Lichens: Might be considered as a source of gastroprotective molecules?

Beatriz Sepulveda, Maria Cristina Chamy, Marisa Piovano, Carlos Areche

Resultado de la investigación: Article

4 Citas (Scopus)

Resumen

Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.

Idioma originalEnglish
Páginas (desde-hasta)1750-1752
Número de páginas3
PublicaciónJournal of the Chilean Chemical Society
Volumen58
N.º2
DOI
EstadoPublished - 1 ene 2013

Huella dactilar

Molecules
Depsides
Lansoprazole
Algae
Metabolites
Fungi
Lichens
Ethanol
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Citar esto

Sepulveda, Beatriz ; Chamy, Maria Cristina ; Piovano, Marisa ; Areche, Carlos. / Lichens : Might be considered as a source of gastroprotective molecules?. En: Journal of the Chilean Chemical Society. 2013 ; Vol. 58, N.º 2. pp. 1750-1752.
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Lichens : Might be considered as a source of gastroprotective molecules? / Sepulveda, Beatriz; Chamy, Maria Cristina; Piovano, Marisa; Areche, Carlos.

En: Journal of the Chilean Chemical Society, Vol. 58, N.º 2, 01.01.2013, p. 1750-1752.

Resultado de la investigación: Article

TY - JOUR

T1 - Lichens

T2 - Might be considered as a source of gastroprotective molecules?

AU - Sepulveda, Beatriz

AU - Chamy, Maria Cristina

AU - Piovano, Marisa

AU - Areche, Carlos

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.

AB - Lichens are symbiotic relationship between fungi and algae or cyanobacteria. Secondary metabolites from lichens are known as lichen substances. We investigated depsidone and depside from lichens 1-6 in the context of their action to prevent gastric ulcer on the model of HCl/ethanol in mice for the first time. Doses of 30 mg/kg of lichen substances 1-6 and positive control (lansoprazole) significantly diminished the lesion index compared with negative control (treated only with HCl/EtOH). Lobaric acid 1, atranorin 2 and psoromic acid 5 reduced the gastric lesions by 76%, 63% and 65%, while for variolaric acid 3, diffractaic acid 4 and perlatolic acid 6 their values were 32%, 14% and 45%, respectively. Our results suggest that lichens have potential as a suite of gastroprotective molecules.

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