Laminin inhibits amyloid-β-peptide fibrillation

Francisca C. Bronfman, Jorge Garrido, Alejandra Alvarez, Carlos Morgan, Nibaldo C. Inestrosa

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

54 Citas (Scopus)

Resumen

Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-β-peptide (Aβ) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/Aβ protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit Aβ fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.

Idioma originalInglés
Páginas (desde-hasta)201-203
Número de páginas3
PublicaciónNeuroscience Letters
Volumen218
N.º3
DOI
EstadoPublicada - 8 nov 1996
Publicado de forma externa

Áreas temáticas de ASJC Scopus

  • Neurociencia (todo)

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