Lactulose hydrogen breath test and functional symptoms in pediatric patients

Ana María Madrid, Gabriela Klapp, Carlos Defilippi, Glauben Landskron, Alvaro Reyes, Carolina Pizarro

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

5 Citas (Scopus)


Background The role of small intestinal bacterial overgrowth (SIBO) in functional digestive disorders in the pediatric population is a matter of controversy, since methods currently used to establish this diagnosis are difficult to interpret. The aim of this work was to analyze the characteristics of the lactulose H 2 breath test (LHBT) in children with functional gastrointestinal symptoms according to more recent criteria. Methods Seventy-two patients and 17 controls were enrolled. A questionnaire was administered regarding digestive symptoms (abdominal pain, bloating, vomiting, and bowel-movement disorders). A lactose hydrogen breath test was performed to rule out lactose malabsorption and a LHBT was used to measure the time elapsed between lactulose oral ingestion and an increment of H 2 concentration of 20 ppm over basal. Results There were no differences of age and gender between patients and controls. Mean time to 20-ppm change was shorter in patients (56.3 ± 3 min) compared to healthy children (74.7 ± 5 min), p < 0.05. In 39% of patients, rise of H 2 occurred during the first 40 min after lactulose ingestion, and in almost all controls, an increment was observed between 50 and 90 min (p < 0.05). Symptoms were unrelated to time to 20-ppm change. Conclusions An abnormal LHBT was found in children with functional symptoms of the digestive tract, but the exact mechanism involved, accelerated intestinal transit or SIBO, needs to be confirmed by an additional method.

Idioma originalInglés
Páginas (desde-hasta)1330-1335
Número de páginas6
PublicaciónDigestive Diseases and Sciences
EstadoPublicada - 1 may. 2012

Áreas temáticas de ASJC Scopus

  • Fisiología
  • Gastroenterología


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