Resumen
A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. (C) 2000 Wiley-liss, Inc.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 235-239 |
Número de páginas | 5 |
Publicación | American Journal of Medical Genetics - Neuropsychiatric Genetics |
Volumen | 96 |
N.º | 2 |
DOI | |
Estado | Publicada - 3 abr. 2000 |
Áreas temáticas de ASJC Scopus
- Genética (clínica)
- Psiquiatría y salud mental
- Neurociencia celular y molecular