Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer

Claudia Riedel, Orsolya Dohán, Antonio De la Vieja, Christopher S. Ginter, Nancy Carrasco

Resultado de la investigación: Contribución a una revistaArtículo de revisiónrevisión exhaustiva

55 Citas (Scopus)

Resumen

The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

Idioma originalInglés
Páginas (desde-hasta)490-496
Número de páginas7
PublicaciónTrends in Biochemical Sciences
Volumen26
N.º8
DOI
EstadoPublicada - 1 ago 2001

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular

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