TY - JOUR
T1 - Journey of the iodide transporter NIS
T2 - From its molecular identification to its clinical role in cancer
AU - Riedel, Claudia
AU - Dohán, Orsolya
AU - De la Vieja, Antonio
AU - Ginter, Christopher S.
AU - Carrasco, Nancy
N1 - Funding Information:
C.R. was supported by the United States ARMY Medical Research and Materiel Command Office Award BC990754. This work was supported by the National Institutes of Health DK-41544 (N.C.).
PY - 2001/8/1
Y1 - 2001/8/1
N2 - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.
AB - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.
UR - http://www.scopus.com/inward/record.url?scp=0035425520&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(01)01904-1
DO - 10.1016/S0968-0004(01)01904-1
M3 - Review article
C2 - 11504625
AN - SCOPUS:0035425520
SN - 0968-0004
VL - 26
SP - 490
EP - 496
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -