Iron homeostasis strategies in acidophilic iron oxidizers: Studies in Acidithiobacillus and Leptospirillum

Hector Osorio, Verónica Martínez, Felipe A. Veloso, Inti Pedroso, Jorge Valdés, Eugenia Jedlicki, David S. Holmes, Raquel Quatrini

Resultado de la investigación: Article

9 Citas (Scopus)

Resumen

An understanding of the physiology and metabolic complexity of microbial consortia involved in metal solubilization is a prerequisite for the rational improvement of bioleaching technologies. Among the most challenging aspects that remain to be addressed is how aerobic acidophiles, especially Fe(II)-oxidizers, contend with the paradoxical hazards of iron overload and iron deficiency, each with deleterious consequences for growth. Homeostatic mechanisms regulating the acquisition, utilization/oxidation, storage and intracellular mobilization of cellular iron are deemed to be critical for fitness and survival of bioleaching microbes. In an attempt to contribute to the comprehensive understanding of the biology and ecology of the microbial communities in bioleaching econiches, we have used comparative genomics and other bioinformatic tools to reconstruct the iron management strategies in newly sequenced Acidithiobacilli and other biomining genomes available in public databases. Species specific genes have been identified with distinctive functional roles in iron management as well as genes shared by several species in biomining consortia. Their analysis contributes to our understanding of the general survival strategies in acidic and iron loaded environments and suggests functions for genes with currently unknown roles that might reveal novel aspects of iron response in acidophiles. Comprehensive examination of the occurrence and conservation of regulatory functions and regulatory sites also allowed the prediction of the metal regulatory networks for these biomining microbes.

Idioma originalEnglish
Páginas (desde-hasta)175-179
Número de páginas5
PublicaciónHydrometallurgy
Volumen94
N.º1-4
DOI
EstadoPublished - 1 nov 2008

Huella dactilar

Iron
Bioleaching
Genes
Metals
Physiology
Ecology
Bioinformatics
Conservation
Hazards
Oxidation

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering
  • Metals and Alloys
  • Materials Chemistry

Citar esto

Osorio, H., Martínez, V., Veloso, F. A., Pedroso, I., Valdés, J., Jedlicki, E., ... Quatrini, R. (2008). Iron homeostasis strategies in acidophilic iron oxidizers: Studies in Acidithiobacillus and Leptospirillum. Hydrometallurgy, 94(1-4), 175-179. https://doi.org/10.1016/j.hydromet.2008.05.038
Osorio, Hector ; Martínez, Verónica ; Veloso, Felipe A. ; Pedroso, Inti ; Valdés, Jorge ; Jedlicki, Eugenia ; Holmes, David S. ; Quatrini, Raquel. / Iron homeostasis strategies in acidophilic iron oxidizers : Studies in Acidithiobacillus and Leptospirillum. En: Hydrometallurgy. 2008 ; Vol. 94, N.º 1-4. pp. 175-179.
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abstract = "An understanding of the physiology and metabolic complexity of microbial consortia involved in metal solubilization is a prerequisite for the rational improvement of bioleaching technologies. Among the most challenging aspects that remain to be addressed is how aerobic acidophiles, especially Fe(II)-oxidizers, contend with the paradoxical hazards of iron overload and iron deficiency, each with deleterious consequences for growth. Homeostatic mechanisms regulating the acquisition, utilization/oxidation, storage and intracellular mobilization of cellular iron are deemed to be critical for fitness and survival of bioleaching microbes. In an attempt to contribute to the comprehensive understanding of the biology and ecology of the microbial communities in bioleaching econiches, we have used comparative genomics and other bioinformatic tools to reconstruct the iron management strategies in newly sequenced Acidithiobacilli and other biomining genomes available in public databases. Species specific genes have been identified with distinctive functional roles in iron management as well as genes shared by several species in biomining consortia. Their analysis contributes to our understanding of the general survival strategies in acidic and iron loaded environments and suggests functions for genes with currently unknown roles that might reveal novel aspects of iron response in acidophiles. Comprehensive examination of the occurrence and conservation of regulatory functions and regulatory sites also allowed the prediction of the metal regulatory networks for these biomining microbes.",
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Osorio, H, Martínez, V, Veloso, FA, Pedroso, I, Valdés, J, Jedlicki, E, Holmes, DS & Quatrini, R 2008, 'Iron homeostasis strategies in acidophilic iron oxidizers: Studies in Acidithiobacillus and Leptospirillum', Hydrometallurgy, vol. 94, n.º 1-4, pp. 175-179. https://doi.org/10.1016/j.hydromet.2008.05.038

Iron homeostasis strategies in acidophilic iron oxidizers : Studies in Acidithiobacillus and Leptospirillum. / Osorio, Hector; Martínez, Verónica; Veloso, Felipe A.; Pedroso, Inti; Valdés, Jorge; Jedlicki, Eugenia; Holmes, David S.; Quatrini, Raquel.

En: Hydrometallurgy, Vol. 94, N.º 1-4, 01.11.2008, p. 175-179.

Resultado de la investigación: Article

TY - JOUR

T1 - Iron homeostasis strategies in acidophilic iron oxidizers

T2 - Studies in Acidithiobacillus and Leptospirillum

AU - Osorio, Hector

AU - Martínez, Verónica

AU - Veloso, Felipe A.

AU - Pedroso, Inti

AU - Valdés, Jorge

AU - Jedlicki, Eugenia

AU - Holmes, David S.

AU - Quatrini, Raquel

PY - 2008/11/1

Y1 - 2008/11/1

N2 - An understanding of the physiology and metabolic complexity of microbial consortia involved in metal solubilization is a prerequisite for the rational improvement of bioleaching technologies. Among the most challenging aspects that remain to be addressed is how aerobic acidophiles, especially Fe(II)-oxidizers, contend with the paradoxical hazards of iron overload and iron deficiency, each with deleterious consequences for growth. Homeostatic mechanisms regulating the acquisition, utilization/oxidation, storage and intracellular mobilization of cellular iron are deemed to be critical for fitness and survival of bioleaching microbes. In an attempt to contribute to the comprehensive understanding of the biology and ecology of the microbial communities in bioleaching econiches, we have used comparative genomics and other bioinformatic tools to reconstruct the iron management strategies in newly sequenced Acidithiobacilli and other biomining genomes available in public databases. Species specific genes have been identified with distinctive functional roles in iron management as well as genes shared by several species in biomining consortia. Their analysis contributes to our understanding of the general survival strategies in acidic and iron loaded environments and suggests functions for genes with currently unknown roles that might reveal novel aspects of iron response in acidophiles. Comprehensive examination of the occurrence and conservation of regulatory functions and regulatory sites also allowed the prediction of the metal regulatory networks for these biomining microbes.

AB - An understanding of the physiology and metabolic complexity of microbial consortia involved in metal solubilization is a prerequisite for the rational improvement of bioleaching technologies. Among the most challenging aspects that remain to be addressed is how aerobic acidophiles, especially Fe(II)-oxidizers, contend with the paradoxical hazards of iron overload and iron deficiency, each with deleterious consequences for growth. Homeostatic mechanisms regulating the acquisition, utilization/oxidation, storage and intracellular mobilization of cellular iron are deemed to be critical for fitness and survival of bioleaching microbes. In an attempt to contribute to the comprehensive understanding of the biology and ecology of the microbial communities in bioleaching econiches, we have used comparative genomics and other bioinformatic tools to reconstruct the iron management strategies in newly sequenced Acidithiobacilli and other biomining genomes available in public databases. Species specific genes have been identified with distinctive functional roles in iron management as well as genes shared by several species in biomining consortia. Their analysis contributes to our understanding of the general survival strategies in acidic and iron loaded environments and suggests functions for genes with currently unknown roles that might reveal novel aspects of iron response in acidophiles. Comprehensive examination of the occurrence and conservation of regulatory functions and regulatory sites also allowed the prediction of the metal regulatory networks for these biomining microbes.

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KW - Comparative genomics

KW - Fe(II)-oxidizers

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KW - Leptospirilli

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