Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice

Hugo F. Miranda, Fernando Sierralta, Sebastian Lux, Rocío Troncoso, Natalia Ciudad, Ramiro Zepeda, Pilar Zanetta, Viviana Noriega, Juan Carlos Prieto

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

Background: Pain is one of the most common problems in clinical medicine. There is considerable evidence that pharmacologic approaches are the most widely used therapeutic options to ameliorate persistent or chronic pain. In this study it was evaluated the effect of l-NAME and naltrexone in the antinociception induced by administration of gabapentin in the orofacial formalin test of mice. Methods: The algesiometer assay was performed by the administration of 20 μl of 2% formalin solution injected into the upper right lip of each mouse. Results: The dose of gabapentin that produces the 50% of the maximum possible effect (ED50) was significantly increased by the pretreatment with l-NAME or naltrexone. Conclusions: These results suggest that gabapentin produce antinociception partly via the activation nitridergic pathways and opioid system.

Idioma originalInglés
Páginas (desde-hasta)399-403
Número de páginas5
PublicaciónPharmacological Reports
Volumen67
N.º2
DOI
EstadoPublicada - abr. 2015

Áreas temáticas de ASJC Scopus

  • Farmacología

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