Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease

Danielle M. Bartlett, Juan F. Domínguez D, Alvaro Reyes, Pauline Zaenker, Kirk W. Feindel, Robert U. Newton, Anthony J. Hannan, James A. Slater, Peter R. Eastwood, Alpar S. Lazar, Mel Ziman, Travis Cruickshank

Resultado de la investigación: Article

Resumen

Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington's disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens.

IdiomaEnglish
Páginas1-8
Número de páginas8
PublicaciónNeurobiology of Sleep and Circadian Rhythms
Volumen6
DOI
EstadoPublished - 1 ene 2019

Huella dactilar

Huntington Disease
Circadian Rhythm
Sleep
Melatonin
Hydrocortisone
Hypothalamus
Actigraphy
Pathology
Body Composition
Wrist
Longitudinal Studies
Consensus
Cross-Sectional Studies
Magnetic Resonance Imaging

Keywords

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Neurology
    • Clinical Neurology
    • Behavioral Neuroscience

    Citar esto

    Bartlett, Danielle M. ; Domínguez D, Juan F. ; Reyes, Alvaro ; Zaenker, Pauline ; Feindel, Kirk W. ; Newton, Robert U. ; Hannan, Anthony J. ; Slater, James A. ; Eastwood, Peter R. ; Lazar, Alpar S. ; Ziman, Mel ; Cruickshank, Travis. / Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease. En: Neurobiology of Sleep and Circadian Rhythms. 2019 ; Vol. 6. pp. 1-8.
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    title = "Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease",
    abstract = "Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington's disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens.",
    keywords = "Circadian rhythm, Huntington's disease, Hypothalamus, Magnetic resonance imaging, Sleep",
    author = "Bartlett, {Danielle M.} and {Dom{\'i}nguez D}, {Juan F.} and Alvaro Reyes and Pauline Zaenker and Feindel, {Kirk W.} and Newton, {Robert U.} and Hannan, {Anthony J.} and Slater, {James A.} and Eastwood, {Peter R.} and Lazar, {Alpar S.} and Mel Ziman and Travis Cruickshank",
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    Bartlett, DM, Domínguez D, JF, Reyes, A, Zaenker, P, Feindel, KW, Newton, RU, Hannan, AJ, Slater, JA, Eastwood, PR, Lazar, AS, Ziman, M & Cruickshank, T 2019, 'Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease' Neurobiology of Sleep and Circadian Rhythms, vol. 6, pp. 1-8. https://doi.org/10.1016/j.nbscr.2018.07.001

    Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease. / Bartlett, Danielle M.; Domínguez D, Juan F.; Reyes, Alvaro; Zaenker, Pauline; Feindel, Kirk W.; Newton, Robert U.; Hannan, Anthony J.; Slater, James A.; Eastwood, Peter R.; Lazar, Alpar S.; Ziman, Mel; Cruickshank, Travis.

    En: Neurobiology of Sleep and Circadian Rhythms, Vol. 6, 01.01.2019, p. 1-8.

    Resultado de la investigación: Article

    TY - JOUR

    T1 - Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington's disease

    AU - Bartlett, Danielle M.

    AU - Domínguez D, Juan F.

    AU - Reyes, Alvaro

    AU - Zaenker, Pauline

    AU - Feindel, Kirk W.

    AU - Newton, Robert U.

    AU - Hannan, Anthony J.

    AU - Slater, James A.

    AU - Eastwood, Peter R.

    AU - Lazar, Alpar S.

    AU - Ziman, Mel

    AU - Cruickshank, Travis

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington's disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens.

    AB - Objective: Pathological changes within the hypothalamus have been proposed to mediate circadian rhythm and habitual sleep disturbances in individuals with Huntington's disease (HD). However, investigations examining the relationships between hypothalamic volume and circadian rhythm and habitual sleep in individuals with HD are sparse. This study aimed to comprehensively evaluate the relationships between hypothalamic pathology and circadian rhythm and habitual sleep disturbances in individuals with premanifest HD. Methods: Thirty-two individuals with premanifest HD and twenty-nine healthy age- and gender-matched controls participated in this dual-site, cross-sectional study. Magnetic resonance imaging scans were performed to evaluate hypothalamic volume. Circadian rhythm and habitual sleep were assessed via measurement of morning and evening cortisol and melatonin levels, wrist-worn actigraphy, the Consensus Sleep Diary and sleep questionnaires. Information on mood, physical activity levels and body composition were also collected. Results: Compared to healthy controls, individuals with premanifest HD displayed significantly reduced grey matter volume in the hypothalamus, decreased habitual sleep efficiency and increased awakenings; however, no alterations in morning cortisol or evening melatonin release were noted in individuals with premanifest HD. While differences in the associations between hypothalamic volume and cortisol and melatonin output existed in individuals with premanifest HD compared to healthy controls, no consistent associations were observed between hypothalamic volume and circadian rhythm or habitual sleep outcomes. Conclusion: While significant differences in associations between hypothalamic volume and cortisol and melatonin existed between individuals with premanifest HD and healthy controls, no differences in circadian markers were observed between the groups. This suggests that circadian regulation is maintained despite hypothalamic pathology, perhaps via neural compensation. Longitudinal studies are required to further understand the relationships between the hypothalamus and circadian rhythm and habitual sleep disturbances in HD as the disease course lengthens.

    KW - Circadian rhythm

    KW - Huntington's disease

    KW - Hypothalamus

    KW - Magnetic resonance imaging

    KW - Sleep

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    EP - 8

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    T2 - Neurobiology of Sleep and Circadian Rhythms

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    SN - 2451-9944

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