Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

M. Mollerach; M. Regueira; L. Bonofiglio; R. Callejo; J. Pace; J. L. Di Fabio; S. Hollingshead; D. Briles; M. Tregnaghi; L. Balbi de Aguirre; E. Aprá; M. Vazquez; L. Galanternic; A. Procopio; D. Logarzo; A. Meccia; C. Kremer; C. Perez; N. Cusa; A. Villagra de Trejo; M. Lura de Calafell; J. Pierini de Gaite; R. Fabre; M. Bruno; R. Dalamón; N. Diaz; M. Noriega; D. Gomez; C. Candas; S. Kaufman; S. Francioni; J. Barrio; M. Romanazzi; L. Erica; E. Barrientos; A. Littvik; A. Fuster; M. Vallejo; W. Krause; C. Nobile; S. Brasili; S. Manganello; M. Escobar; E. Aguirre; A. Brú; C. Carranza; N. Salazar; V. David

doi:10.1017/S0950268803001626

Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

M. Mollerach, M. Regueira, L. Bonofiglio, R. Callejo, J. Pace, J. L. Di Fabio, S. Hollingshead, D. Briles, M. Tregnaghi, L. Balbi de Aguirre, E. Aprá, M. Vazquez, L. Galanternic, A. Procopio, D. Logarzo, A. Meccia, C. Kremer, C. Perez, N. Cusa, A. Villagra de TrejoM. Lura de Calafell, J. Pierini de Gaite, R. Fabre, M. Bruno, R. Dalamón, N. Diaz, M. Noriega, D. Gomez, C. Candas, S. Kaufman, S. Francioni, J. Barrio, M. Romanazzi, L. Erica, E. Barrientos, A. Littvik, A. Fuster, M. Vallejo, W. Krause, C. Nobile, S. Brasili, S. Manganello, M. Escobar, E. Aguirre, A. Brú, C. Carranza, N. Salazar, V. David

Facultad Medicina

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29 Citas (Scopus)

Resumen

PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

Idioma original	Inglés
Páginas (desde-hasta)	177-184
Número de páginas	8
Publicación	Epidemiology and Infection
Volumen	132
N.º	2
DOI	https://doi.org/10.1017/S0950268803001626
Estado	Publicada - 1 abr. 2004

Áreas temáticas de ASJC Scopus

Epidemiología
Enfermedades infecciosas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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10.1017/S0950268803001626

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Mollerach, M., Regueira, M., Bonofiglio, L., Callejo, R., Pace, J., Di Fabio, J. L., Hollingshead, S., Briles, D., Tregnaghi, M., Balbi de Aguirre, L., Aprá, E., Vazquez, M., Galanternic, L., Procopio, A., Logarzo, D., Meccia, A., Kremer, C., Perez, C., Cusa, N., ... David, V. (2004). Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity. Epidemiology and Infection, 132(2), 177-184. https://doi.org/10.1017/S0950268803001626

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title = "Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity",

abstract = "PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.",

author = "M. Mollerach and M. Regueira and L. Bonofiglio and R. Callejo and J. Pace and {Di Fabio}, {J. L.} and S. Hollingshead and D. Briles and M. Tregnaghi and {Balbi de Aguirre}, L. and E. Apr{\'a} and M. Vazquez and L. Galanternic and A. Procopio and D. Logarzo and A. Meccia and C. Kremer and C. Perez and N. Cusa and {Villagra de Trejo}, A. and {Lura de Calafell}, M. and {Pierini de Gaite}, J. and R. Fabre and M. Bruno and R. Dalam{\'o}n and N. Diaz and M. Noriega and D. Gomez and C. Candas and S. Kaufman and S. Francioni and J. Barrio and M. Romanazzi and L. Erica and E. Barrientos and A. Littvik and A. Fuster and M. Vallejo and W. Krause and C. Nobile and S. Brasili and S. Manganello and M. Escobar and E. Aguirre and A. Br{\'u} and C. Carranza and N. Salazar and V. David",

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Mollerach, M, Regueira, M, Bonofiglio, L, Callejo, R, Pace, J, Di Fabio, JL, Hollingshead, S, Briles, D, Tregnaghi, M, Balbi de Aguirre, L, Aprá, E, Vazquez, M, Galanternic, L, Procopio, A, Logarzo, D, Meccia, A, Kremer, C, Perez, C, Cusa, N, Villagra de Trejo, A, Lura de Calafell, M, Pierini de Gaite, J, Fabre, R, Bruno, M, Dalamón, R, Diaz, N, Noriega, M, Gomez, D, Candas, C, Kaufman, S, Francioni, S, Barrio, J, Romanazzi, M, Erica, L, Barrientos, E, Littvik, A, Fuster, A, Vallejo, M, Krause, W, Nobile, C, Brasili, S, Manganello, S, Escobar, M, Aguirre, E, Brú, A, Carranza, C, Salazar, N & David, V 2004, 'Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity', Epidemiology and Infection, vol. 132, n.º 2, pp. 177-184. https://doi.org/10.1017/S0950268803001626

Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity. / Mollerach, M.; Regueira, M.; Bonofiglio, L. et al.
En: Epidemiology and Infection, Vol. 132, N.º 2, 01.04.2004, p. 177-184.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Invasive Streptococcus pneumoniae isolates from Argentinian children

T2 - Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

AU - Mollerach, M.

AU - Regueira, M.

AU - Bonofiglio, L.

AU - Callejo, R.

AU - Pace, J.

AU - Di Fabio, J. L.

AU - Hollingshead, S.

AU - Briles, D.

AU - Tregnaghi, M.

AU - Balbi de Aguirre, L.

AU - Aprá, E.

AU - Vazquez, M.

AU - Galanternic, L.

AU - Procopio, A.

AU - Logarzo, D.

AU - Meccia, A.

AU - Kremer, C.

AU - Perez, C.

AU - Cusa, N.

AU - Villagra de Trejo, A.

AU - Lura de Calafell, M.

AU - Pierini de Gaite, J.

AU - Fabre, R.

AU - Bruno, M.

AU - Dalamón, R.

AU - Diaz, N.

AU - Noriega, M.

AU - Gomez, D.

AU - Candas, C.

AU - Kaufman, S.

AU - Francioni, S.

AU - Barrio, J.

AU - Romanazzi, M.

AU - Erica, L.

AU - Barrientos, E.

AU - Littvik, A.

AU - Fuster, A.

AU - Vallejo, M.

AU - Krause, W.

AU - Nobile, C.

AU - Brasili, S.

AU - Manganello, S.

AU - Escobar, M.

AU - Aguirre, E.

AU - Brú, A.

AU - Carranza, C.

AU - Salazar, N.

AU - David, V.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

AB - PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

UR - http://www.scopus.com/inward/record.url?scp=11144358582&partnerID=8YFLogxK

U2 - 10.1017/S0950268803001626

DO - 10.1017/S0950268803001626

M3 - Article

C2 - 15061491

AN - SCOPUS:11144358582

SN - 0950-2688

VL - 132

SP - 177

EP - 184

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 2

ER -

Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

Resumen

Áreas temáticas de ASJC Scopus

ODS de las Naciones Unidas

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