Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity

M. Mollerach, M. Regueira, L. Bonofiglio, R. Callejo, J. Pace, J. L. Di Fabio, S. Hollingshead, D. Briles, M. Tregnaghi, L. Balbi de Aguirre, E. Aprá, M. Vazquez, L. Galanternic, A. Procopio, D. Logarzo, A. Meccia, C. Kremer, C. Perez, N. Cusa, A. Villagra de TrejoM. Lura de Calafell, J. Pierini de Gaite, R. Fabre, M. Bruno, R. Dalamón, N. Diaz, M. Noriega, D. Gomez, C. Candas, S. Kaufman, S. Francioni, J. Barrio, M. Romanazzi, L. Erica, E. Barrientos, A. Littvik, A. Fuster, M. Vallejo, W. Krause, C. Nobile, S. Brasili, S. Manganello, M. Escobar, E. Aguirre, A. Brú, C. Carranza, N. Salazar, V. David

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

27 Citas (Scopus)

Resumen

PspA is an antigenically variable virulence factor of Streptococcus pneumoniae that inhibits complement deposition and is a potential candidate for human vaccines. Of 64 published strains 96% are in PspA families 1 and 2; optimal protection is family-specific. Effective development of a PspA-containing vaccine requires more information about the PspA family of strains in parts of the world where the vaccine is most needed. In these studies we observed that of 149 isolates (of 19 capsular types) from Argentina, 54.4% were family 1, 41.6% were family 2 and 4.0% expressed both family 1 and family 2 PspAs. Box typing revealed the Argentinian strains to be from at least 10 clonally related groups.

Idioma originalInglés
Páginas (desde-hasta)177-184
Número de páginas8
PublicaciónEpidemiology and Infection
Volumen132
N.º2
DOI
EstadoPublicada - 1 abr 2004

Áreas temáticas de ASJC Scopus

  • Epidemiología
  • Enfermedades infecciosas

Huella

Profundice en los temas de investigación de 'Invasive Streptococcus pneumoniae isolates from Argentinian children: Serotypes, families of pneumococcal surface protein A (PspA) and genetic diversity'. En conjunto forman una huella única.

Citar esto