Intranuclear trafficking: Organization and assembly of regulatory machinery for combinatorial biological control

Sayyed K. Zaidi, Daniel W. Young, Je Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Gary S. Stein

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

26 Citas (Scopus)

Resumen

The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

Idioma originalInglés
Páginas (desde-hasta)43363-43366
Número de páginas4
PublicaciónJournal of Biological Chemistry
Volumen279
N.º42
DOI
EstadoPublicada - 15 oct 2004

Áreas temáticas de ASJC Scopus

  • Bioquímica
  • Biología molecular
  • Biología celular

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