Intestinal microbiota influences non-intestinal related autoimmune diseases

Maria C. Opazo, Elizabeth M. Ortega-Rocha, Irenice Coronado-Arrázola, Laura C. Bonifaz, Helene Boudin, Michel Neunlist, Susan M. Bueno, Alexis M. Kalergis, Claudia A. Riedel

Resultado de la investigación: Review article

37 Citas (Scopus)

Resumen

The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases.

Idioma originalEnglish
Número de artículo432
PublicaciónFrontiers in Microbiology
Volumen9
N.ºMAR
DOI
EstadoPublished - 12 mar 2018

Huella dactilar

Microbiota
Autoimmune Diseases
Immune System
Dysbiosis
Intestinal Diseases
Nasal Cavity
Graves Disease
Type 1 Diabetes Mellitus
Human Body
Psoriasis
Crohn Disease
Systemic Lupus Erythematosus
Multiple Sclerosis
Intestines
Mouth
Schizophrenia
Homeostasis
Gastrointestinal Microbiome
Pathology
Bacteria

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Citar esto

Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., ... Riedel, C. A. (2018). Intestinal microbiota influences non-intestinal related autoimmune diseases. Frontiers in Microbiology, 9(MAR), [432]. https://doi.org/10.3389/fmicb.2018.00432
Opazo, Maria C. ; Ortega-Rocha, Elizabeth M. ; Coronado-Arrázola, Irenice ; Bonifaz, Laura C. ; Boudin, Helene ; Neunlist, Michel ; Bueno, Susan M. ; Kalergis, Alexis M. ; Riedel, Claudia A. / Intestinal microbiota influences non-intestinal related autoimmune diseases. En: Frontiers in Microbiology. 2018 ; Vol. 9, N.º MAR.
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Opazo, MC, Ortega-Rocha, EM, Coronado-Arrázola, I, Bonifaz, LC, Boudin, H, Neunlist, M, Bueno, SM, Kalergis, AM & Riedel, CA 2018, 'Intestinal microbiota influences non-intestinal related autoimmune diseases', Frontiers in Microbiology, vol. 9, n.º MAR, 432. https://doi.org/10.3389/fmicb.2018.00432

Intestinal microbiota influences non-intestinal related autoimmune diseases. / Opazo, Maria C.; Ortega-Rocha, Elizabeth M.; Coronado-Arrázola, Irenice; Bonifaz, Laura C.; Boudin, Helene; Neunlist, Michel; Bueno, Susan M.; Kalergis, Alexis M.; Riedel, Claudia A.

En: Frontiers in Microbiology, Vol. 9, N.º MAR, 432, 12.03.2018.

Resultado de la investigación: Review article

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AU - Bueno, Susan M.

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AU - Riedel, Claudia A.

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N2 - The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases.

AB - The human body is colonized by millions of microorganisms named microbiota that interact with our tissues in a cooperative and non-pathogenic manner. These microorganisms are present in the skin, gut, nasal, oral cavities, and genital tract. In fact, it has been described that the microbiota contributes to balancing the immune system to maintain host homeostasis. The gut is a vital organ where microbiota can influence and determine the function of cells of the immune system and contributes to preserve the wellbeing of the individual. Several articles have emphasized the connection between intestinal autoimmune diseases, such as Crohn's disease with dysbiosis or an imbalance in the microbiota composition in the gut. However, little is known about the role of the microbiota in autoimmune pathologies affecting other tissues than the intestine. This article focuses on what is known about the role that gut microbiota can play in the pathogenesis of non-intestinal autoimmune diseases, such as Grave's diseases, multiple sclerosis, type-1 diabetes, systemic lupus erythematosus, psoriasis, schizophrenia, and autism spectrum disorders. Furthermore, we discuss as to how metabolites derived from bacteria could be used as potential therapies for non-intestinal autoimmune diseases.

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Opazo MC, Ortega-Rocha EM, Coronado-Arrázola I, Bonifaz LC, Boudin H, Neunlist M y otros. Intestinal microbiota influences non-intestinal related autoimmune diseases. Frontiers in Microbiology. 2018 mar 12;9(MAR). 432. https://doi.org/10.3389/fmicb.2018.00432